Multiple mechanisms underlie burst firing in rat midbrain doparnine neurons in vitro
Multiple mechanisms underlie burst firing in rat midbrain doparnine neurons in vitro
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DOI：
10.1016/j.brainres.2004.06.022
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发表时间：
2004-09-03
期刊：
影响因子：
2.9
通讯作者：
Wu, YN
中科院分区：
文献类型：
--
作者：
Johnson, SW;Wu, YN
在大鼠中脑切片中，apamin和NMDA都能引起多巴胺神经元胞内记录的爆发放电。然而，阿帕明诱导的爆发需要注射去极化电流，并模仿湾K8644和硝苯地平阻断。相反，NMDA诱导的爆发需要超极化电流，硝苯地平不能阻断。我们的研究结果表明，可以通过两种不同的机制诱发多巴胺神经元的爆发性放电。(C)2004 Elsevier B.V.保留所有权利。
Both apamin and NMDA evoke burst firing in dopamine neurons recorded intracellularly in slices of rat midbrain. However, apamin-induced bursting required injection of depolarizing currents, and was mimicked by Bay K8644 and blocked by nifedipine. In contrast, NMDA-induced bursting required hyperpolarizing currents and was not blocked by nifedipine. Our results show that burst firing can be evoked in dopamine neurons via two different mechanisms. (C) 2004 Elsevier B.V. All rights reserved.