The relationship between upper leg muscle strength and walking capacity in persons with multiple sclerosis
The relationship between upper leg muscle strength and walking capacity in persons with multiple sclerosis
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DOI：
10.1177/1352458512444497
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发表时间：
2013-01-01
影响因子：
5.8
通讯作者：
Feys, Peter
中科院分区：
文献类型：
--
作者：
Broekmans, Tom;Gijbels, Domien;Feys, Peter
背景资料：在人与多发性硬化症（PwMS）阻力训练提高肌肉力量，但对步行能力的影响是unconsistent.Objective：目的是确定不同类型的大腿肌肉力量测量和步行能力之间的关系在PwMS.Methods：一个观察性横断面研究设计。采用等长（膝伸肌和屈肌）和等速（膝伸肌）测力法测量52例PwMS（扩展残疾状态量表，EDSS范围1.5-6.5）的上肢肌肉力量。步行能力的评估使用定时25英尺步行，定时起身和走和两分钟步行测试。区分轻度（EDSS 1.5-4.0，n=31）和中度（EDSS 4.5-6.5，n=21）行走功能障碍亚组，并假设结果因多发性硬化（MS）相关残疾状态而异。结果：中度MS组与轻度MS组的Pearson相关系数最大（r：0.2-0.7），且有显著性差异。在膝伸肌的测量，它被发现，等速耐力最好的步行能力。当比较最大等长肌力测量值时，膝屈肌（r：0.5-0.7）与步行能力的相关性优于膝伸肌（r：0.1-0.4）。回归分析证实耐力膝伸肌的力量（类似于25%）和等距膝屈肌的力量（类似于40%）的主要预测因素为walking capacity.Conclusion：阻力训练方案可以考虑列入演习集中在耐力膝伸肌和等距膝屈肌的力量时，旨在提高步行能力的人中度步行功能障碍。
Background: In persons with multiple sclerosis (PwMS) resistance training improves muscle strength but effects on walking capacity are inconsistent.Objective: The objective was to determine the relation between different types of upper leg muscle strength measurements and walking capacity in PwMS.Methods: An observational cross-sectional study design was applied. Upper leg muscle strength of 52 PwMS (Expanded Disability Status Scale, EDSS range 1.5-6.5) was measured using isometric (knee extensors and flexors) and isokinetic (knee extensors) dynamometry. Walking capacity was assessed using the Timed 25-Foot Walk, Timed Up and Go and Two Minute Walk Test. Subgroups with mild (EDSS 1.5-4.0, n=31) and moderate (EDSS 4.5-6.5, n=21) ambulatory dysfunction were distinguished, and results were hypothesized to differ depending on multiple sclerosis (MS)-related disability status. Correlation and regression analyses were performed on the data of the most affected leg.Results: Greatest (r:0.2-0.7) and significant Pearson correlation coefficients were found in the moderate compared to mild MS subgroup. Within knee extensor measurements, it was found that isokinetic endurance strength related best to walking capacity. When comparing maximal isometric strength measurements, knee flexors (r:0.5-0.7) related better to walking capacity than knee extensors (r:0.1-0.4). Regression analyses confirmed endurance knee extensor strength (similar to 25 %) and isometric knee flexor strength (similar to 40%) as main predictors for walking capacity.Conclusion: Resistance training protocols may consider inclusion of exercises focusing on endurance knee extensor and isometric knee flexor strength when aiming to enhance walking capacity in persons with moderate ambulatory dysfunction.