Effects of methylphenidate on functional MRI blood-oxygen-level-dependent contrast.
Effects of methylphenidate on functional MRI blood-oxygen-level-dependent contrast.
复制标题
哌醋甲酯对功能性 MRI 血氧水平依赖性对比度的影响。
DOI：
10.1176/appi.ajp.157.10.1697
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Stein,EA
中科院分区：
文献类型：
--
作者：
Rao,SM;Salmeron,BJ;Durgerian,S;Janowiak,JA;Fischer,M;Risinger,RC;Conant,LL;Stein,EA
作者的目的是确定哌醋甲酯对功能性磁共振成像（MRI）血氧水平依赖（BOLD）对比度的潜在血流动力学后果。方法记录6名健康受试者右食指屈伸运动时运动皮层的BOLD和灌注变化。在口服哌甲酯给药之前和之后，以不同的速率（手指敲击）测量MRI信号。受试者的心率增加适度哌甲酯管理后，但没有变化，手指敲击性能或功能性MRI信号observed.CONCLUSIONSSMethylphenidate不改变BOLD神经血流动力学耦合。因此，功能性MRI可用于映射有助于认知操作的神经系统（例如，注意力和执行过程）。
OBJECTIVEThe authors’ goal was to determine potential hemodynamic consequences of methylphenidate on functional magnetic resonance imaging (MRI) blood-oxygen-level-dependent (BOLD) contrast.METHODBOLD and perfusion changes were recorded from the motor cortex of six healthy subjects while they performed flexion-extension movements of the right index finger (finger tapping) at varying rates before and after oral methylphenidate administration.RESULTSFunctional MRI signals increased monotonically with faster movement rates. Subjects’ heart rates increased modestly after methylphenidate administration, but no changes in finger tapping performance or functional MRI signals were observed.CONCLUSIONSMethylphenidate does not alter BOLD neural-hemodynamic coupling. Consequently, functional MRI can be used to map neural systems that subserve cognitive operations (e.g., attention and executive processes) in subjects taking methylphenidate.