Liberal or Restrictive Transfusion after Cardiac Surgery
Liberal or Restrictive Transfusion after Cardiac Surgery
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DOI：
10.1056/nejmoa1403612
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发表时间：
2015-03-12
影响因子：
158.5
通讯作者：
Reeves, Barnaby C.
中科院分区：
文献类型：
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作者：
Murphy, Gavin J.;Pike, Katie;Reeves, Barnaby C.
背景：与自由阈值相比，红细胞输血中血红蛋白水平的限制性阈值是否能降低心脏手术后的发病率和医疗费用尚不确定。方法：我们进行了一项多中心、平行组试验，从英国17个中心招募了16岁以上接受非急诊心脏手术的患者。术后血红蛋白水平低于9 g / dl的患者被随机分配到限制性输血阈值（血红蛋白水平）
BACKGROUNDWhether a restrictive threshold for hemoglobin level in red-cell transfusions, as compared with a liberal threshold, reduces postoperative morbidity and health care costs after cardiac surgery is uncertain.METHODSWe conducted a multicenter, parallel-group trial in which patients older than 16 years of age who were undergoing nonemergency cardiac surgery were recruited from 17 centers in the United Kingdom. Patients with a postoperative hemoglobin level of less than 9 g per deciliter were randomly assigned to a restrictive transfusion threshold (hemoglobin level