The mechanism of the paralysing action of tetramisole on Ascaris somatic muscle
The mechanism of the paralysing action of tetramisole on Ascaris somatic muscle
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四咪唑对蛔虫体肌的麻痹作用机制
DOI：
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发表时间：
1970
影响因子：
7.3
通讯作者：
R. Martinez
中科院分区：
文献类型：
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作者：
J. Aceves;D. Erlij;R. Martinez
1 .四咪唑（100 μg/ml）在3 min内使活蛔虫麻痹。四咪唑（10 μg/ml）引起离体虫体肌肉的持续收缩。箭毒和哌嗪都不能阻断这种收缩。3 .第三章。四咪唑使蛔虫肌静息电位由34 ± 4 mV降至10 ± 1 mV。四、四咪唑引起蛔虫肌肉收缩先前去极化与高K+的解决方案。这一观察结果表明，四咪唑可以诱导挛缩，是独立的膜去极化。
1 . Tetramisole (100 μg/ml) paralysed live Ascaris in 3 min. 2 . Tetramisole (10 μg/ml) caused a sustained contraction of the isolated somatic muscles of the worm. This contraction was not blocked by curare nor by piperazine. 3 . Tetramisole reduced the resting potential of Ascaris muscle from 34 ± 4 to 10 ± 1 mV. 4 . Tetramisole caused contraction of Ascaris muscle previously depolarized with high K+ solutions. This observation suggests that tetramisole can induce a contracture that is independent of membrane depolarization.