Effect of flaxseed and wheat bran on serum hormones and lignan excretion in premenopausal women
Effect of flaxseed and wheat bran on serum hormones and lignan excretion in premenopausal women
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DOI：
10.1080/07315724.2003.10719335
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发表时间：
2003-12-01
影响因子：
3.5
通讯作者：
Slavin, JL
中科院分区：
文献类型：
--
作者：
Frische, EJ;Hutchins, AM;Slavin, JL
目的：研究亚麻籽(一种富含木脂素的植物性食物)单独食用以及与麦皮联合食用对绝经前妇女血清激素和尿木脂素排泄的影响。方法：采用随机、交叉设计，对16名受试者进行为期两个月经周期的4种喂养方式的研究。在每次治疗期间，受试者每天食用他们的习惯饮食，辅以不含亚麻籽或麦皮的烘焙食品，10克亚麻籽，28克麦皮，或10克亚麻籽+28克麦皮。在每次饮食治疗的第二个月经周期的黄体中期采集的血清样本进行了血清激素和性激素结合球蛋白的分析。对同一时间段采集的尿样进行木脂素排泄分析。结果：两种治疗方法的血清激素浓度和性激素结合球蛋白水平均无明显变化。含有亚麻籽的饮食处理组尿木脂素排泄量显著增加，但添加小麦麸皮对木脂素排泄量无显著影响。结论：在这组绝经前妇女中，尿木脂素排泄量随着亚麻籽摄入量的增加而增加，但血清激素水平没有变化。食用含有亚麻籽的小麦麸皮不会改变与亚麻籽食用相关的尿木脂素排泄。
Objective: To examine the effects of flaxseed consumption (a lignan-rich plant food) alone and in combination with wheat bran on serum hormones and urinary lignan excretion in premenopausal women.Methods: Sixteen subjects were studied for four feeding treatments lasting two menstrual cycles each in a randomized, crossover design. During each treatment, subjects consumed their habitual diets supplemented with baked goods containing no flaxseed or wheat bran, 10 g of flaxseed, 28 g of wheat bran, or 10 g of flaxseed plus 28 g of wheat bran/day. Serum samples collected during the mid-luteal phase of the second menstrual cycle of each diet treatment were analyzed for serum hormones and sex hormone binding globulin. Urine samples collected during the same time period were analyzed for urinary lignan excretion.Results: There were no changes in serum hormone concentrations or sex hormone binding globulin on any of the treatments. Urinary lignan excretion significantly increased on diet treatments that included flaxseed, but inclusion of wheat bran did not significantly alter lignan excretion.Conclusions: Urinary lignan excretion increased with flaxseed consumption, but serum hormones did not change in this group of premenopausal women. Consumption of wheat bran with flaxseed did not alter urinary lignan excretion associated with flaxseed consumption.