Melatonin administration in insomnia.
Melatonin administration in insomnia.
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褪黑激素在失眠中的应用。
作者：
S. P. James;D. Sack;N. Rosenthal;W. Mendelson
10名持续性失眠患者采用随机双盲设计，观察口服1 mg和5 mg褪黑素对脑电记录睡眠的影响。受试者在第二天的睡眠开始或持续时间没有任何变化，也没有对情绪或警觉性产生任何影响。在1毫克剂量下，快速眼动(REM)潜伏期显著增加，尽管REM睡眠的其他参数没有受到影响。患者报告说，在两种褪黑激素状态下，他们的睡眠都较少。尽管感觉到了下降，但据报道，总体主观素质有所改善。
Ten patients with persistent insomnia were randomized in a double-blind design and the effects of 1-mg and 5-mg oral dosages of melatonin on the electroencephalogram-recorded sleep were examined. Subjects showed no changes in either the onset or duration of sleep, nor any effect on mood or alertness the following day. A significant increase in rapid-eye-movement (REM) latency was noted at the 1-mg dose, though no other parameter of REM sleep was affected. The patients reported less sleep on both melatonin conditions. Despite this perception of decrease, overall subjective quality was reported to be improved.