Advances in the stimuli-responsive injectable hydrogel for controlled release of drugs.
Advances in the stimuli-responsive injectable hydrogel for controlled release of drugs.
复制标题
用于药物控制释放的刺激响应可注射水凝胶的进展。
DOI：
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发表时间：
2022
影响因子：
4.6
通讯作者：
Yuping Chen
中科院分区：
文献类型：
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作者：
Chunxiang Mo;Rui Luo;Yuping Chen
可注射水凝胶的刺激响应性在药物的控制释放方面得到了极大的发展，并在包括创伤、心血管疾病和肿瘤在内的多种疾病中取得了令人鼓舞的疗效。这种水凝胶的凝胶化、溶胀和降解响应于内源性生化因素（例如pH、活性氧物质、谷胱甘肽、酶、葡萄糖）和/或响应于外源性物理刺激（如光、磁、电和超声），从而响应于特定病理状态并根据治疗计划的需要准确地释放负载的药物，从而有效地提高治疗功效。本文详细介绍了近年来响应性注射水凝胶的研究进展，重点介绍了各种刺激敏感性的设计策略及其对凝胶解离和药物释放行为的影响。并讨论了它们在疾病治疗中的应用。本文受版权保护。All rights reserved.
The stimuli-responsiveness of injectable hydrogel has been drastically developed for the controlled release of drugs and achieved encouraging curative effects in a variety of diseases including wounds, cardiovascular diseases and tumors. The gelation, swelling and degradation of such hydrogels respond to endogenous biochemical factors (such as pH, reactive oxygen species, glutathione, enzymes, glucose) and/or to exogenous physical stimulations (like light, magnetism, electricity and ultrasound), thereby accurately releasing loaded drugs in response to specifically pathological status and as desired for treatment plan and thus improving therapeutic efficacy effectively. In this paper, we give a detailed introduction of recent progresses in responsive injectable hydrogels and focus on the design strategy of various stimuli-sensitivities and their resultant alteration of gel dissociation and drug liberation behaviour. Their application in disease treatment is also discussed. This article is protected by copyright. All rights reserved.