Electrochemical Ruthenium-Catalysed Directed C-H Functionalization of Arenes with Boron Reagents
Electrochemical Ruthenium-Catalysed Directed C-H Functionalization of Arenes with Boron Reagents
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DOI：
10.1002/adsc.202301184
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发表时间：
2024-01-04
影响因子：
5.4
通讯作者：
Larrosa，Igor
中科院分区：
文献类型：
--
作者：
Kenyon，Jacob;Larrosa，Igor
在钌催化下，通过氧化诱导的还原消除机制，实现了具有硼基偶联配偶体的芳族化合物的邻位定向电化学C-H官能化。我们的方法提供了一组条件，提供C-H芳基化，烯基化和甲基化，产生具有良好官能团耐受性的邻位官能化产物，包括合成有用产率的后期官能化的例子。通过利用电力作为“绿色”氧化剂，这种方法避免了化学计量数量的化学氧化剂的需要，提高了我们的可持续性指标。
Ortho‐directed electrochemical C−H functionalization of aromatics with boron‐based coupling partners has been achieved under ruthenium catalysis through an oxidatively induced reductive elimination mechanism. Our method provides a single set of conditions delivering C−H arylation, alkenylation and methylation, yieldingortho‐functionalized products with good functional group tolerance, including examples of late‐stage functionalization in synthetically useful yields. By harnessing electricity as a ‘green’ oxidant, this method circumvents the need for stoichiometric quantities of chemical oxidants, enhancing our sustainability metrics.