In vivo assessment of neovascularization of liver metastases using perfusion CT
In vivo assessment of neovascularization of liver metastases using perfusion CT
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DOI：
10.1259/bjr.71.843.9616236
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发表时间：
1998-03-01
影响因子：
2.6
通讯作者：
Bunce, I
中科院分区：
文献类型：
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作者：
Miles, KA;Leggett, DAC;Bunce, I
肿瘤的新血管形成产生高的微血管密度。虽然诊断成像无法直接显示微血管，但可以显示组织灌注的相关变化。本研究的目的是利用灌注CT的定量功能信息和高空间分辨率来研究肝转移瘤的新生血管。对13例不同原发肿瘤肝转移患者进行了灌注CT检查，测量了转移灶的动脉灌注，在紧邻转移灶的小边缘肝组织中测量了动脉和门静脉灌注。在9例病例中，灌注测量值与患者的生存率相关。转移灶和邻近肝脏的动脉灌注均高于正常值（中位数：0.62 ml min（-1）ml（-1）;范围：0.26-3.05 ml min（-1）ml（-1））和（中位数：0.51 ml min（-1）ml（-1）;范围：0.14-1.60 ml min（-1）ml（-1））。邻近肝脏的门静脉灌注变化很大（中位数：0.30 ml min（-1）ml（-1）;范围：0.05-1.85 ml min（-1）ml（-1））。转移灶周围肝组织内动脉灌注与门静脉灌注呈正相关（p
Neovascularization of tumours produces a high microvessel density. Although diagnostic imaging is unable to visualize microvessels directly, it is possible to demonstrate associated changes in tissue perfusion. The aim of this study was to use the quantitative functional information and high spatial resolution of perfusion computed tomography to study neovascularization of hepatic metastases. Perfusion CT was performed in 13 patients with hepatic metastases from various primary tumours, Arterial perfusion was measured in the metastasis; both arterial and portal perfusion were measured in a small rim of liver tissue immediately adjacent to the metastasis. Perfusion measurements were correlated against survival of the patient in nine cases. Arterial perfusion was increased above normal values, both in the metastasis (median: 0.62 ml min(-1) ml(-1); range: 0.26-3.05 ml min(-1) ml(-1)) and in the adjacent liver (median: 0.51 ml min(-1) ml(-1); range: 0.14-1.60 ml min(-1) ml(-1)). Portal perfusion of adjacent liver was highly variable (median: 0.30 ml min(-1) ml(-1); range: 0.05-1.85 ml min(-1) ml(-1)). Arterial perfusion was positively correlated with portal perfusion within liver tissue adjacent to metastases (p