The predictive value of interleukin-8 (IL-8) in hospitalised patients with fever and chemotherapy-induced neutropenia
The predictive value of interleukin-8 (IL-8) in hospitalised patients with fever and chemotherapy-induced neutropenia
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DOI：
10.1016/j.ejca.2008.10.041
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发表时间：
2009-03-01
影响因子：
8.4
通讯作者：
Vellenga, Edo
中科院分区：
文献类型：
--
作者：
Tromp, Yvonne H.;Daenen, Simon M. G. J.;Vellenga, Edo
目的：证明血清白细胞介素 8 (IL-8) 是否是选择感染概率低或高的化疗引起的中性粒细胞减少性发热住院患者的相关参数。结果：对 73 名患者的 90 次可评估发热发作进行了评估； 46% 的发热发作为微生物记录感染 (MDI)，8% 为临床记录感染 (CDI)，47% 为不明原因发热 (FUO)。与 CDI 和 MDI 相比，FUO 组的中位 IL-8 水平较低 (p < 0.0005)。在 48 例 CDI/MDI 发作中，有 45 例 (94%) 开始时 IL-8 水平 >= 60 ng/l，而在 21 例 IL-8 水平 = 60 ng/l 且对抗生素治疗有反应的发作中，有 18 例 (86%) 与无反应患者相比，几天内 IL-8 水平下降。结论：血清 IL-8 水平可以作为识别住院患者的有用标志物 FUO患者感染概率较低。 (C) 2008 Elsevier Ltd. 保留所有权利。
Aim: To demonstrate whether serum Interleukin-8 (IL-8) is a relevant parameter to select hospitalised patients with chemotherapy-induced neutropenic fever with low or high probability of infection.Results: 90 assessable febrile episodes in 73 patients were evaluated; 46% of the febrile episodes were microbiologically documented infection (MDI), 8% clinical documented infection (CDI), and 47% fever of unknown origin (FUO). Median IL-8 level was lower in the FUO group compared to CDI and MDI (p < 0.0005). In 45 of 48 episodes (94%) with CDI/MDI, IL-8 level at the start was >= 60 ng/l while in 18 of 21 episodes (86%) with IL-8 level = 60 ng/l and responsive on antibiotic treatment showed a decline of IL-8 levels within days in contrast to non-responding patients.Conclusions: Serum IL-8 level can be a useful marker to identify hospitalised FUO patients with low probability of infection. (C) 2008 Elsevier Ltd. All rights reserved.