Epigenetic abnormalities in myeloproliferative neoplasms: a target for novel therapeutic strategies.
Epigenetic abnormalities in myeloproliferative neoplasms: a target for novel therapeutic strategies.
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骨髓增生性肿瘤的表观遗传异常：新型治疗策略的靶标。
DOI：
10.1007/s13148-011-0050-6
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发表时间：
2011-08
影响因子：
5.7
通讯作者：
Hoffman R
中科院分区：
文献类型：
--
作者：
Mascarenhas J;Roper N;Chaurasia P;Hoffman R
The myeloproliferative neoplasms (MPNs) are a group of clonal hematological malignancies characterized by a hypercellular bone marrow and a tendency to develop thrombotic complications and to evolve to myelofibrosis and acute leukemia. Unlike chronic myelogenous leukemia, where a single disease-initiating genetic event has been identified, a more complicated series of genetic mutations appear to be responsible for the BCR-ABL1-negative MPNs which include polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Recent studies have revealed a number of epigenetic alterations that also likely contribute to disease pathogenesis and determine clinical outcome. Increasing evidence indicates that alterations in DNA methylation, histone modification, and microRNA expression patterns can collectively influence gene expression and potentially contribute to MPN pathogenesis. Examples include mutations in genes encoding proteins that modify chromatin structure (EZH2, ASXL1, IDH1/2, JAK2V617F, and IKZF1) as well as epigenetic modification of genes critical for cell proliferation and survival (suppressors of cytokine signaling, polycythemia rubra vera-1, CXC chemokine receptor 4, and histone deacetylase (HDAC)). These epigenetic lesions serve as novel targets for experimental therapeutic interventions. Clinical trials are currently underway evaluating HDAC inhibitors and DNA methyltransferase inhibitors for the treatment of patients with MPNs.
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影响因子：
11.2
作者：
Abdel-Wahab O;Manshouri T;Patel J;Harris K;Yao J;Hedvat C;Heguy A;Bueso-Ramos C;Kantarjian H;Levine RL;Verstovsek S
通讯作者：
Verstovsek S
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
20.3
作者：
Chou, Wen-Chien;Hou, Hsin-An;Tien, Hwei-Fang
通讯作者：
Tien, Hwei-Fang
影响因子：
11.5
作者：
Chase, Andrew;Cross, Nicholas C. P.
通讯作者：
Cross, Nicholas C. P.
影响因子：
11.2
作者：
Bumm, Thomas G. P.;Elsea, Collin;Deininger, Michael W. N.
通讯作者：
Deininger, Michael W. N.