BDNF G196A (Val66Met) polymorphism associated with cognitive impairment in Parkinson's disease
BDNF G196A (Val66Met) polymorphism associated with cognitive impairment in Parkinson's disease
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DOI：
10.1016/j.neulet.2013.12.051
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发表时间：
2014-02-21
影响因子：
2.5
通讯作者：
Slawek, Jarostaw
中科院分区：
文献类型：
--
作者：
Bialecka, Monika;Kurzawski, Mateusz;Slawek, Jarostaw
脑源性神经营养因子（brain -derived neurotrophic factor， BDNF）是一种在哺乳动物大脑中广泛表达的神经营养因子，调节神经元存活，并影响多巴胺能神经元和认知过程。本研究探讨了BDNF Val66Met多态性与PD风险和PD认知障碍的关系。共纳入486名研究对象（244名PD和242名年龄和性别匹配的对照组）。UPDRS评分、Hoehn-Yahr分期和Schwab-England量表用于评估日常生活中的运动能力和活动。根据神经心理学评价将患者分为痴呆组（PDD, n = 69）和非痴呆组（nPDD, n = 166）。采用Taq-Man实时荧光定量PCR法检测BDNF Val66Met （rs6265, G196A）基因最常见的功能多态性。PD组和对照组中评估的BDNF等位基因和基因型频率相似。BDNF Met/Met携带者的平均发病年龄（65.00 +/- 6.13）晚于Val/Val（57.45 +/- 10.68）和Val/Met（56.33 +/- 10.91）受试者（p = 0.077）。所研究的BDNF多态性与PD患者的认知状态无关。然而，Met/Met等位基因的患者比Val/Val等位基因的患者表现出更好的信息延迟回忆。多因素logistic回归分析结果显示，年龄（p = 0.0003）和疾病分期（p = 0.002）是PD痴呆的独立危险因素。2014爱思唯尔爱尔兰有限公司版权所有。
Brain-derived neurotrophic factor (BDNF) is a neurotrophin widely expressed in the mammalian brain, regulating neuronal survival and known to influence dopaminergic neurons and cognitive processes. The present study investigated the BDNF Val66Met polymorphism associations with PD risk, and cognitive impairment in PD. A total of 486 study subjects (244 PD and 242 age and sex matched controls) were included in the study. UPDRS score, Hoehn-Yahr staging and the Schwab-England scale were used to assess motor abilities and activity during daily life. The patients were classified into groups with dementia (PDD, n = 69) and without it (nPDD, n = 166) on the basis of neuropsychological assessment. The Most common functional polymorphism in BDNF Val66Met (rs6265, G196A) gene was determined using Taq-Man real-time PCR assay. Frequencies of evaluated BDNF alleles and genotypes were similar in PD and the controls. The mean age of disease onset among BDNF Met/Met carriers was later (65.00 +/- 6.13) in comparison to Val/Val (57.45 +/- 10.68) and Val/Met (56.33 +/- 10.91) subjects (p = 0.077). The studied BDNF polymorphism was not associated with cognitive status in PD patients. However, patients with Met/Met alleles demonstrated better delayed recall of information than patients with Val/Val alleles. The results of multivariate logistic regression analysis revealed age (p = 0.0003) and the disease stage (p = 0.002) as independent risk factors predisposing to PD dementia. (C) 2014 Elsevier Ireland Ltd. All rights reserved.