Helicobacter pylori and lung function, asthma, atopy and allergic diseaseA population-based cross-sectional study in adults
Helicobacter pylori and lung function, asthma, atopy and allergic diseaseA population-based cross-sectional study in adults
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DOI：
10.1093/ije/dyn348
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发表时间：
2009-04-01
影响因子：
7.7
通讯作者：
Fogarty, Andrew W.
中科院分区：
文献类型：
--
作者：
Fullerton, Donna;Britton, John R.;Fogarty, Andrew W.
背景暴露于微生物可导致免疫系统两极分化，降低哮喘和相关过敏性疾病的风险，而暴露于幽门螺杆菌则被认为增加了阻塞性呼吸道疾病的风险。方法随机抽取2 437名成人，对其过敏性疾病症状、用力呼气量(FEV1)、用力肺活量(FVC)、支气管反应性、变应原皮肤致敏、血清Ig E和Hp血清学状态进行分析。结果有Hp血清学证据的个体肺功能降低，FEV1降低53ml(95 CI 110 6)，FVC降低83 ml(95 CI 20145)。在对身高或社会经济地位进行调整后，这些差异在统计上不再显著。在横断面分析中，幽门螺杆菌血清学状态与哮喘或特应性疾病的程度之间没有关联，也没有发现幽门螺杆菌血清学状态与9年来FEV1和FVC的下降有显著的相关性。结论尽管幽门螺杆菌感染可能与较低的横断面FEV1和FVC有关，但这种关联并不独立于身高或社会经济地位。幽门螺杆菌感染与慢性阻塞性肺疾病(COPD)、过敏性疾病的指标或肺功能下降之间没有关联。
Background Exposure to microbes may result in the polarization of the immune system and a decrease in the risk of asthma and associated allergic disease, whilst exposure to Helicobacter pylori has been hypothesized to increase the risk of obstructive airways disease. We tested the hypotheses that exposure to H. pylori reduces the risk of asthma and allergic disease and is associated with a decrease in lung function.Methods Data were collected on allergic disease symptoms, forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), bronchial reactivity, allergen skin sensitization, serum IgE and H. pylori serological status in 2437 randomly selected adults.Results Individuals with serological evidence of exposure to H. pylori had lower lung function, FEV1 being lower by 53 ml (95 CI 1106) and FVC 83 ml (95 CI 20145) lower in the cross-sectional analysis. These differences ceased to be statistically significant after adjustment for height or socio-economic status. There was no association between H. pylori serological status and measures of asthma or atopy in the cross-sectional analysis, and there was no significant association between H. pylori serological status and decline in FEV1 and FVC over 9 years.Conclusion Although H. pylori exposure may be associated with lower cross-sectional FEV1 and FVC, this association was not independent of height or socio-economic status. There was no association between H. pylori exposure and either chronic obstructive pulmonary disease (COPD), measures of allergic disease or decline in lung function.