Reconciling the numbers: ESTs versus protein-coding genes
Reconciling the numbers: ESTs versus protein-coding genes
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DOI：
10.1093/molbev/msh125
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发表时间：
2004-07-01
影响因子：
10.7
通讯作者：
Nekrutenko, A
中科院分区：
文献类型：
--
作者：
Nekrutenko, A
表达序列的数量大大超过了哺乳动物基因组中蛋白质编码基因的估计数量。一种进化方法显示，只有9%到14%的人类表达和小鼠表达的序列能够编码蛋白质。使用跨物种关系对这些序列进行聚类表明，数百万个表达序列可能仅对应于大约20，000个不同的蛋白质编码转录本。
The number of expressed sequences greatly surpasses the estimated number of protein-coding genes in mammalian genomes. An evolutionary approach reveals that only 9% to 14% of human-expressed and mouse-expressed sequences are able to code for proteins. Clustering of these sequences using cross-species relationships suggests that millions of expressed sequences may correspond to only approximately 20,000 distinct protein-coding transcripts.