Alterations in brain and immune function produced by mindfulness meditation
Alterations in brain and immune function produced by mindfulness meditation
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DOI：
10.1097/01.psy.0000077505.67574.e3
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发表时间：
2003-07-01
影响因子：
3.3
通讯作者：
Sheridan, JF
中科院分区：
文献类型：
--
作者：
Davidson, RJ;Kabat-Zinn, J;Sheridan, JF
目的：与冥想所引起的心理和身体健康变化相关的生物过程的潜在变化尚未得到系统探究。我们针对一项知名且广泛应用的为期8周的正念冥想临床训练项目对健康员工工作环境中的大脑和免疫功能的影响进行了一项随机对照研究。
方法：我们在一项为期8周的正念冥想训练项目之前、之后即刻以及4个月后测量大脑电活动。冥想组有25名受试者接受测试。一个等待名单对照组（N = 16）在与冥想者相同的时间点接受测试。在8周结束时，两组受试者都接种流感疫苗。
结果：我们首次报告，与非冥想者相比，冥想者左侧前部激活显著增加，这种模式先前与积极情感相关。我们还发现，与等待名单对照组相比，冥想组受试者的流感疫苗抗体滴度显著增加。最后，左侧激活增加的幅度可预测疫苗抗体滴度上升的幅度。
结论：这些发现表明，一个短期的正念冥想项目对大脑和免疫功能产生了明显的影响。这些发现提示冥想可能以积极的方式改变大脑和免疫功能，并强调了进一步研究的必要性。
Objective: The underlying changes in biological processes that are associated with reported changes in mental and physical health in response to meditation have not been systematically explored. We performed a randomized, controlled study on the effects on brain and immune function of a well-known and widely used 8-week clinical training program in mindfulness meditation applied in a work environment with healthy employees. Methods: We measured brain electrical activity before and immediately after, and then 4 months after an 8-week training program in mindfulness meditation. Twenty-five subjects were tested in the meditation group. A wait-list control group (N = 16) was tested at the same points in time as the meditators. At the end of the 8-week period, subjects in both groups were vaccinated with influenza vaccine. Results: We report for the first time significant increases in left-sided anterior activation, a pattern previously associated with positive affect, in the meditators compared with the nonmeditators. We also found significant increases in antibody titers to influenza vaccine among subjects in the meditation compared with those in the wait-list control group. Finally, the magnitude of increase in left-sided activation predicted the magnitude of antibody titer rise to the vaccine. Conclusions: These findings demonstrate that a short program in mindfulness meditation produces demonstrable effects on brain and immune function. These findings suggest that meditation may change brain and immune function in positive ways and underscore the need for additional research.