On the interactions between mesenchymal stem cells and regulatory T cells for immunomodulation in transplantation.
On the interactions between mesenchymal stem cells and regulatory T cells for immunomodulation in transplantation.
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关于间充质干细胞和调节性T细胞之间的相互作用，以进行移植中的免疫调节。
DOI：
10.3389/fimmu.2012.00126
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发表时间：
2012
影响因子：
7.3
通讯作者：
Hoogduijn MJ
中科院分区：
文献类型：
--
作者：
Engela AU;Baan CC;Dor FJ;Weimar W;Hoogduijn MJ
实验研究已经确定使用间充质干细胞(MSC)作为候选的免疫抑制疗法。MSC通过抑制CD4+和CD8+T细胞的增殖发挥其免疫调节功能。目前尚不清楚MSC是否损害调节性T细胞(Treg)的免疫抑制功能。体外和体内研究表明，MSC通过诱导Treg介导其免疫调节作用。在这篇综述中，我们将集中在MSC和Treg之间的相互作用，并评估这些细胞相互作用对器官移植中MSC免疫治疗的影响。
Experimental studies have established the use of mesenchymal stem cells (MSC) as a candidate immunosuppressive therapy. MSC exert their immunomodulatory function through the inhibition of CD4+ and CD8+ T cell proliferation. It is unknown whether MSC impair the immunosuppressive function of regulatory T cells (Treg). In vitro and in vivo studies suggest that MSC mediate their immunomodulatory effects through the induction of Treg. In this review we will focus on the interactions between MSC and Treg, and evaluate the consequences of these cellular interplays for prospective MSC immunotherapy in organ transplantation.