A neurohormone regulating both methyl farnesoate synthesis and glucose metabolism in a crustacean
A neurohormone regulating both methyl farnesoate synthesis and glucose metabolism in a crustacean
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DOI：
10.1006/bbrc.1997.6977
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发表时间：
1997-08-28
影响因子：
3.1
通讯作者：
Hayes, T
中科院分区：
文献类型：
--
作者：
Liu, L;Laufer, H;Hayes, T
金合欢酸甲酯（MF）是甲壳类动物体内的一种幼鱼样化合物，对甲壳类动物的发育和繁殖具有重要的调控作用。为了研究MF合成的调控，我们从蜘蛛蟹的神经血管器官-窦腺X器官复合体中分离到一种抑制MF合成的神经肽。这种神经肽的一级结构已经确定。它有72个氨基酸残基（推导分子量8490.5 Da），N-末端为焦谷氨酸，C-末端为NH 2。它与形成甲壳动物CHH神经肽独特家族的其他窦腺神经肽具有高百分比的序列同一性。活性研究表明，这种神经激素具有双重作用：它在体外抑制MF合成，并在注入螃蟹时具有高血糖活性。(C)北京：科学出版社.
Methyl farnesoate (MF) has been identified as a juvenile hormone-like compound in crustacea which has central roles in the regulation of development and reproduction. To study the regulation of MF synthesis, we isolated a neuropeptide which inhibits MF synthesis from the neurohemal organ-sinus gland X-organ complex of the spider crab Libinia emarginata. The primary structure of this neuropeptide has been determined. It has 72 amino acid residues (deduced molecular mass 8490.5 Da) with pyroglutamic acid at the N-terminus and NH2 at the C-terminus. It shares a high percentage of sequence identity with other sinus gland neuropeptids which form the unique family of CHH neuropeptides of crustacea. Activity studies showed that this neurohormone has dual effects: it inhibited MF synthesis in vitro and had hyperglycemic activity when injected into crabs. (C) 1997 Academic Press.