CORONAVIRIDAE
CORONAVIRIDAE
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DOI：
10.1159/000149390
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发表时间：
1983-01-01
期刊：
影响因子：
4.6
通讯作者：
VANDERZEIJST, BAM
中科院分区：
文献类型：
--
作者：
SIDDELL, SG;ANDERSON, R;VANDERZEIJST, BAM
冠状病毒科由11种感染脊椎动物的病毒组成。描述了成员病毒的主要特征。包膜多形性颗粒，通常直径100纳米（范围60-220纳米），轴承约。20nm长的棒状表面突起。这些病毒具有。apprx基因组RNA的单链感染分子。(5 - 7)同学们。106兆瓦。它们还具有一个磷酸化的核衣壳蛋白[MW，（50-60）倍]。[103]作为螺旋核糖核蛋白与基因组络合；一种表面蛋白，与1或2个糖基化多肽结合[分子量（90-180）倍]。103);和一种跨膜（基质）蛋白，与1个多肽相关，该多肽可能被糖基化到不同程度[MW（20-35）次]。103]。在感染细胞中产生多个3 “共端亚基因组mRNA，沿5 ”方向延伸不同长度。病毒粒子胞浆内萌发。有3种主要抗原，每种抗原对应1类病毒粒子蛋白。冠状病毒主要局限于通过粪便/口腔途径水平传播感染天然脊椎动物宿主。这些病毒主要导致呼吸道和胃肠道疾病。
The family Coronaviridae comprises a monogeneric group of 11 viruses which infect vertebrates. The main characteristics of the member viruses are described. Enveloped pleomorphic particles typically 100 nm in diameter (range 60-220 nm), bearing .apprx. 20 nm long club-shaped surface projections are noted. These viruses have a single-stranded infectious molecule of genomic RNA of .apprx. (5-7) .times. 106 MW. They also possess a phosphorylated nucleocapsid protein [MW, (50-60) .times. 103] complexed with the genome as a helical ribonucleoprotein; a surface (peplomer) protein, associated with 1 or 2 glycosylated polypeptides [MW (90-180) .times. 103]; and a transmembrane (matrix) protein, associated with 1 polypeptide which may be glycosylated to different degrees [MW (20-35) .times. 103]. Production in infected cells consists of multiple 3'' coterminal subgenomic mRNA extending for different lengths in the 5'' direction. Virions bud intracytoplasmically. There are 3 major antigens, each corresponding to 1 class of virion protein. Coronaviruses are predominantly restricted to infection of natural vertebrate hosts by horizontal transmission via the fecal/oral route. These viruses are responsible mainly for respiratory and gastrointestinal disorders.