Tranexamic acid for the prevention and management of orthopedic surgical hemorrhage: current evidence.
Tranexamic acid for the prevention and management of orthopedic surgical hemorrhage: current evidence.
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DOI：
10.2147/jbm.s61915
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发表时间：
2015
影响因子：
2
通讯作者：
Davey JR
中科院分区：
文献类型：
--
作者：
Kim C;Park SS;Davey JR
全关节置换术可能与大量失血有关，术后贫血需要输血。有效和安全地减少失血和减少输血需求的措施将有助于改善患者安全和降低医疗保健成本。在全关节置换术中，减少手术失血的一种可能的药理学选择是使用氨甲环酸。大量文献表明，静脉和/或局部给予氨甲环酸可有效减少失血和输血，且不会增加静脉血栓栓塞事件或其他并发症的风险。
Total joint arthroplasty can be associated with major blood loss and require subsequent blood transfusions for postoperative anemia. Measures to effectively and safely decrease blood loss and reduce the need for blood transfusions would help improve patient safety and lower health care costs. A possible pharmacological option to reduce surgical blood loss in total joint arthroplasty is the use of tranexamic acid. Abundant literature has shown that intravenous and/or topical administration of tranexamic acid is effective in reducing blood loss and blood transfusions, with no increased risk of venous thromboembolic events or other complications.