Co-ordination of cell cycle and differentiation in the developing nervous system.
Co-ordination of cell cycle and differentiation in the developing nervous system.
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DOI：
10.1042/bj20112040
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发表时间：
2012-06-15
期刊：
影响因子：
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通讯作者：
Philpott A
中科院分区：
文献类型：
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作者：
Hindley C;Philpott A
在胚胎发育期间，细胞必须分裂以产生适当数量的细胞，但随后必须退出细胞周期以允许分化。在胚胎发育过程中，这些增殖和分化过程是如何协调的，人们直到最近才了解。然而，许多研究现在已经深入了解细胞周期机制，包括细胞周期蛋白，CDKs（细胞周期蛋白依赖性激酶），CDK抑制剂和其他细胞周期调节因子如何直接影响控制细胞命运和分化的机制。相反，转录调节因子的例子正在出现，这些转录调节因子以其在驱动分化表型中的作用而闻名，它们在控制细胞周期进程中也起着互补作用。本综述将总结我们目前对发育中的神经系统中协调细胞周期和分化的机制的理解，这些联系可能是研究最广泛的。
During embryonic development, cells must divide to produce appropriate numbers, but later must exit the cell cycle to allow differentiation. How these processes of proliferation and differentiation are co-ordinated during embryonic development has been poorly understood until recently. However, a number of studies have now given an insight into how the cell cycle machinery, including cyclins, CDKs (cyclin-dependent kinases), CDK inhibitors and other cell cycle regulators directly influence mechanisms that control cell fate and differentiation. Conversely, examples are emerging of transcriptional regulators that are better known for their role in driving the differentiated phenotype, which also play complementary roles in controlling cell cycle progression. The present review will summarise our current understanding of the mechanisms co-ordinating the cell cycle and differentiation in the developing nervous system, where these links have been, perhaps, most extensively studied.