Active cocaine immunization attenuates the discriminative properties of cocaine
Active cocaine immunization attenuates the discriminative properties of cocaine
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DOI：
10.1037/1064-1297.8.2.163
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发表时间：
2000-05-01
影响因子：
2.3
通讯作者：
Ettinger, RH
中科院分区：
文献类型：
--
作者：
Johnson, MW;Ettinger, RH
使用可卡因-匙孔-血蓝蛋白（KLH）缀合物免疫产生的抗可卡因抗体削弱了可卡因在大鼠中作为辨别刺激的能力。在免疫之前，对受试者进行了广泛的训练以区分 5.0 mg/kg 的可卡因和盐水。使用可卡因-KLH 免疫几周后，受试者无法可靠地区分可卡因和盐水。在整个实验过程中，未免疫的对照大鼠保留了区分可卡因和盐水的能力。这些结果进一步证明主动免疫可以有效减弱可卡因的作用。然而，免疫受试者能够辨别 20 毫克/千克的可卡因，这表明抗可卡因抗体可能会被大剂量的可卡因淹没。
Anticocaine antibody, resulting from immunization with the cocaine-keyhole-limpet hemocyanin (KLH) conjugate, weakened the ability of cocaine to act as a discriminative stimulus in rats. Subjects were given extensive training to discriminate 5.0 mg/kg of cocaine from saline prior to immunization. Several weeks following immunization with cocaine-KLH, subjects failed to reliably discriminate cocaine from saline. Nonimmunized control rats retained the ability to discriminate cocaine from saline throughout the experiment. These results further demonstrate that active immunization is effective in blunting cocaine effects. Immunized subjects were able to discriminate 20 mg/kg of cocaine, however, suggesting that anticocaine antibody may be overwhelmed by large cocaine doses.