BLOCKADE OF COCAINE REINFORCEMENT IN RATS WITH DOPAMINE RECEPTOR BLOCKER PIMOZIDE, BUT NOT WITH NORADRENERGIC BLOCKERS PHENTOLAMINE OR PHENOXYBENZAMINE
BLOCKADE OF COCAINE REINFORCEMENT IN RATS WITH DOPAMINE RECEPTOR BLOCKER PIMOZIDE, BUT NOT WITH NORADRENERGIC BLOCKERS PHENTOLAMINE OR PHENOXYBENZAMINE
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DOI：
10.1037/h0081662
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发表时间：
1977-01-01
期刊：
影响因子：
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通讯作者：
WISE, RA
中科院分区：
文献类型：
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作者：
DEWIT, H;WISE, RA
用多巴胺受体阻断剂匹莫齐特或去甲肾上腺素能阻断剂酚妥拉明或酚苄明处理31只自我施用可卡因的雄性Wistar大鼠。匹莫齐特引起剂量相关（. 0625-. 5 mg/kg）加速反应;在较高剂量下，反应随后停止。匹莫齐特的这些作用与奖励（单位剂量）减少和奖励终止的已知作用平行，因此表明多巴胺能脑机制在可卡因强化的介导中起重要作用。无论是酚苄明全身或酚妥拉明脑室内给予有类似的效果，因此没有类似的作用，去甲肾上腺素能脑机制，这些实验表明。（法文摘要）（25参考文献）（PsycInfo Database Record（c）2022阿帕，all rights reserved）
31 male Wistar rats self-administering cocaine were treated with the dopamine receptor blocker pimozide or the noradrenergic blockers phentolamine or phenoxybenzamine. Pimozide caused a dose-related (. 0625–. 5 mg/kg) acceleration of responding; at the higher doses responding subsequently ceased. These effects of pimozide parallel the known effects of reward (unit dose) reduction and reward termination and thus suggest an important role for dopaminergic brain mechanisms in the mediation of cocaine reinforcement. Neither phenoxybenzamine given systemically nor phentolamine given intraventricularly had similar effects; thus no similar role for noradrenergic brain mechanisms is suggested by these experiments.(French summary)(25 ref)(PsycInfo Database Record (c) 2022 APA, all rights reserved)