LIFE-STYLE RISK-FACTORS FOR PANCREATIC-CANCER IN LOUISIANA - A CASE-CONTROL STUDY
LIFE-STYLE RISK-FACTORS FOR PANCREATIC-CANCER IN LOUISIANA - A CASE-CONTROL STUDY
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DOI：
10.1093/oxfordjournals.aje.a114972
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发表时间：
1988-08-01
影响因子：
5
通讯作者：
FRAUMENI, JF
中科院分区：
文献类型：
--
作者：
FALK, RT;PICKLE, LW;FRAUMENI, JF
1979年至1983年，在路易斯安那州的高危地区进行了一项以医院为基础的胰腺癌病例对照研究，同时进行了类似的肺癌和胃癌研究。为了评估生活方式的做法，包括饮食，作者从三项研究中汇集了控制，然后排除了饮食改变慢性疾病的受试者。当将363例病例与1，234例确定的对照组进行比较时，发现具有Cajun血统的人的风险显着升高，特别是在农村地区。在当前吸烟者中，中度（每天16-25支香烟）和重度（≥ 25支香烟）吸烟者的风险显著增加两倍。26支/天），而戒烟者没有表现出一致的风险模式。在调整了吸烟、饮食和人口统计学因素的潜在混杂因素后，胰腺癌的风险与使用酒精饮料或咖啡无关。猪肉制品和大米是明显的饮食风险因素，每一个都表现出积极的剂量反应效应，而水果消费产生了保护性的影响。
A hospital-based, incident case-control study of pancreatic cancer was conducted between 1979 and 1983 in parallel with similarly designed studies of lung and stomach cancers in high-risk areas of Louisiana. To evaluate life-style practices, including diet, the author pooled controls from the three studies, and then excluded subjects with diet-altering chronic diseases. When the 363 cases were compared with the 1,234 identified controls, significantly elevated risks were found among persons with Cajun ancestry, especially in rural areas. Among current smokers, a significant twofold risk was associated with moderate (16-25 cigarettes per day) and heavy (.gtoreq. 26 cigarettes per day) consumption, while exsmokers showed no consistent pattern of risk. After adjustment for potential confounding by smoking, diet, and demographic factors, the risk of pancreatic cancer was unrelated to use of alcoholic beverages or coffee. Pork products and rice were conspicuous as dietary risk factors, each showing a positive dose-response effect, whereas fruit consumption exerted a protective protective influence.