Resveratrol suppresses hyperoxia-induced nucleocytoplasmic shuttling of SIRT1 and ROS production in PBMC from preterm infants in vitro
Resveratrol suppresses hyperoxia-induced nucleocytoplasmic shuttling of SIRT1 and ROS production in PBMC from preterm infants in vitro
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白藜芦醇在体外抑制早产儿 PBMC 中高氧诱导的 SIRT1 核质穿梭和 ROS 产生
DOI：
10.1080/14767058.2017.1311310
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Ling-Ping Zhang
中科院分区：
文献类型：
--
作者：
Xi Yang;Wen-Bin Dong;Xiao-Ping Lei;Qing-Ping Li;Lian-Yu Zhang;Ling-Ping Zhang
Abstract Objective: By assessing silent mating-type information regulation 2 homolog 1 (SIRT1) nucleocytoplasmic shuttling and reactive oxygen species (ROS) levels in peripheral blood mononuclear cells (PBMCs), this study aimed to explore the role of SIRT1 in premature infants after exposure to hyperoxia and assess the protective effects of resveratrol (Res). Methods: Firstly, ROS levels as well as SIRT1 translocation and expression in PBMCs samples were evaluated from 40 premature infants with different oxygen amounts received at birth. Then, PBMCs, from additional 40 premature infants administered no oxygen at birth, were used to establish an in vitro model of hyperoxia. Results: In infants that received O2 at birth, ROS and MDA levels, and SIRT1 translocation rates gradually increased in a concentration-dependent manner, while SIRT1 gradually decreased. In agreement, PBMCs cultured in vitro showed increased ROS levels after exposed to hyperoxia, SIRT1 translocation increased as well. However, treatment with Res resulted in opposite effects. Conclusion: Res inhibits ROS release in PBMCs from preterm infants exposed to hyperoxia, likely by preventing SIRT1 nucleocytoplasmic shuttling and increasing SIRT1 expression.
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DOI：
10.4172/2153-2435.1000424
发表时间：
2015-10
期刊：
Pharmaceutica analytica acta
影响因子：
--
作者：
Ananddeep Patel;Shaojie Zhang;B. Moorthy;B. Shivanna
通讯作者：
Ananddeep Patel;Shaojie Zhang;B. Moorthy;B. Shivanna
二甲双胍和白藜芦醇通过 SIRT1/p300/p53/p21 通路抑制高血糖诱导的内皮衰老代谢记忆
影响因子：
3.7
作者：
Zhang E;Guo Q;Gao H;Xu R;Teng S;Wu Y
通讯作者：
Wu Y
影响因子：
5.2
作者：
Zhang, Zhen-Ning;Chung, Sun-Ku;Xu, Zheng;Xu, Yang
通讯作者：
Xu, Yang
影响因子：
2.1
作者：
Chong ZZ;Maiese K
通讯作者：
Maiese K
DOI：
10.1152/ajplung.00176.2014
发表时间：
2015-08-15
影响因子：
4.9
作者：
Datta, Ankur;Kim, Gina A.;Berkelhamer, Sara K.
通讯作者：
Berkelhamer, Sara K.