Recent insights into cutaneous immunization: How to vaccinate via the skin
Recent insights into cutaneous immunization: How to vaccinate via the skin
复制标题
DOI：
10.1016/j.vaccine.2015.05.012
复制
发表时间：
2015-09-08
期刊：
影响因子：
5.5
通讯作者：
Engert, Julia
中科院分区：
文献类型：
--
作者：
Engelke, Laura;Winter, Gerhard;Engert, Julia
在过去的几十年中，皮肤疫苗接种的技术和策略已经发生了显著的变化。如今，有证据表明，可减少剂量并提供传统疫苗接种的微创替代方案的可重复递送疫苗的效力增加。在完善的皮肤疫苗接种策略领域内已经取得了相当大的进展：喷射和粉末注射技术、微针、微孔技术、电穿孔、声致穿孔以及透皮和经卵泡疫苗递送。由于最近的进展，皮肤疫苗接种的使用可以从传染病的预防性疫苗接种扩展到传染性和非传染性慢性疾病的治疗性疫苗接种。这篇综述将提供对皮肤中发生的免疫过程的深入了解，并介绍皮肤疫苗接种技术的关键创新。(C)2015爱思唯尔有限公司版权所有。
Technologies and strategies for cutaneous vaccination have been evolving significantly during the past decades. Today, there is evidence for increased efficacy of cutaneously delivered vaccines allowing for dose reduction and providing a minimally invasive alternative to traditional vaccination. Considerable progress has been made within the field of well-established cutaneous vaccination strategies: Jet and powder injection technologies, microneedles, microporation technologies, electroporation, sonoporation, and also transdermal and transfollicular vaccine delivery. Due to recent advances, the use of cutaneous vaccination can be expanded from prophylactic vaccination for infectious diseases into therapeutic vaccination for both infectious and non-infectious chronic conditions. This review will provide an insight into immunological processes occurring in the skin and introduce the key innovations of cutaneous vaccination technologies. (C) 2015 Elsevier Ltd. All rights reserved.