EFFECT OF ETHANOL ON THE INTERACTION BETWEEN THE MACROPHAGE AND MYCOBACTERIUM-AVIUM
EFFECT OF ETHANOL ON THE INTERACTION BETWEEN THE MACROPHAGE AND MYCOBACTERIUM-AVIUM
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DOI：
10.1016/0741-8329(94)90046-9
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发表时间：
1994-03-01
期刊：
影响因子：
2.3
通讯作者：
BERMUDEZ, LE
中科院分区：
文献类型：
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作者：
BERMUDEZ, LE
长期摄入乙醇易患肺结核和细菌性肺炎。鸟分枝杆菌复合体可导致艾滋病患者菌血症。暴露于乙醇的人巨噬细胞和鼠枯否细胞对M.比对照单核吞噬细胞。乙醇也被证明会损害人巨噬细胞和鼠枯否细胞对肿瘤坏死因子（TNF）和粒细胞巨噬细胞集落刺激因子（GM-CSF）刺激的反应能力，并在适当刺激时产生细胞因子，如白细胞介素-1、白细胞介素-6和TNF。这种损伤部分依赖于巨噬细胞膜上TNF受体数量的下调。最近的证据表明，非致死浓度的乙醇诱导M.总之，乙醇在影响感染结果的复杂事件序列中对宿主和分枝杆菌都起作用。
Chronic ethanol ingestion predisposes to tuberculosis and bacterial pneumonia. Mycobacterium avium complex organisms cause bacteremia in patients with AIDS. Human macrophages and murine Kupffer cells exposed to ethanol are more permissive towards intracellular growth of M. avium than control mononuclear phagocytes. Ethanol also has been shown to impair the ability of human macrophages and murine Kupffer cells to respond to stimulation with tumor necrosis factor (TNF) and granulocyte macrophage colony stimulating factor (GM-CSF), and to produce cytokines such as interleukin-1, interleukin-6, and TNF when properly stimulated. The impairment is dependent in part on a downregulation in the number of TNF receptors on the macrophage's membrane. Recent evidence suggests that ethanol in nonlethal concentrations induces stress-related proteins in M. avium, leading to the inhibition of intracellular pathways in the macrophage and, consequently, impairing some of its functions.In summary, ethanol acts both on the host and on the mycobacterium in a complex sequence of events that influence the outcome of the infection.