Cardionatrin causes vasodilation in vitro which is not dependent on the presence of endothelial cells.
Cardionatrin causes vasodilation in vitro which is not dependent on the presence of endothelial cells.
复制标题
心钠素在体外引起血管舒张，这不依赖于内皮细胞的存在。
DOI：
10.1016/0014-2999(84)90040-2
复制
发表时间：
1984
影响因子：
5
通讯作者：
M. Carvalho
中科院分区：
文献类型：
--
作者：
R. Scivoletto;M. Carvalho
在体外，比较了心房提取物(心钠素)与乙酰胆碱和罂粟碱对有内皮和无内皮预收缩大鼠主动脉的松弛作用。脑室提取液检测作为对照。心房提取物和罂粟碱对两种制剂都有相似的浓度依赖的松弛作用，而乙酰胆碱不能松弛无内皮细胞的制剂。脑室提取液对两种制剂均无效。结论：这些制剂对心房提取液(心钠素)的反应不依赖于内皮细胞的存在。文中还讨论了一些病理生理学意义。
Vasolidation, in vitro, evoked by atrial extracts (cardionatrin) was compared with the relaxation due to acetylcholine and papaverine in rat precontracted aortae with and without endothelium. Ventricular extracts were tested as controls. Atrial extracts and papaverine caused a similar concentration-dependent relaxation of both preparations whereas acetylcholine failed to relax preparations without endothelium. Ventricular extracts were ineffective on both preparations. It is concluded that the response of the preparations to atrial extracts (cardionatrin) is not dependent on the presence of the endothelial cells. Some pathophysiological implications are discussed.