Selectivity of the insulin-like actions of vanadate on glucose and protein metabolism in skeletal muscle.
Selectivity of the insulin-like actions of vanadate on glucose and protein metabolism in skeletal muscle.
复制标题
钒酸盐对骨骼肌中葡萄糖和蛋白质代谢的胰岛素样作用的选择性。
DOI：
10.1042/bj2320273
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Mitch,WE
中科院分区：
文献类型：
--
作者：
Clark,AS;Fagan,JM;Mitch,WE
To determine if vanadate has insulin-like actions in skeletal muscle, we measured its effects on glucose and protein metabolism in epitrochlearis muscles of rats. Compared with insulin, vanadate increased glucose uptake, glycogen synthesis and glycolysis to a lesser degree, but caused a greater stimulation of lactate and glucose oxidation. Unlike insulin, vanadate did not change either protein synthesis or degradation. These different metabolic responses could be related to the different pattern of insulin-receptor phosphorylation caused by insulin and vanadate.
