MicroRNAs and Exosomal microRNAs May Be Possible Targets to Investigate in Gestational Diabetes Mellitus.
MicroRNAs and Exosomal microRNAs May Be Possible Targets to Investigate in Gestational Diabetes Mellitus.
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DOI：
10.2147/dmso.s330323
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Wu N
中科院分区：
文献类型：
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作者：
Yang X;Wu N
妊娠期糖尿病（GDM）是指妊娠中期或晚期发生的葡萄糖耐受不良。随着GDM发病率的上升，母亲和胎儿并发症的风险也会增加，并产生短期和长期后果。因此，早期诊断和治疗这种疾病对于避免不良妊娠结局非常重要。外泌体是由活细胞分泌的含有多种生物活性物质的微小囊泡。它们由细胞释放以促进细胞间通讯并调节多种生物过程，例如细胞免疫应答、炎症应答和细胞凋亡等。近年来许多研究证实，外泌体miRNAs表达和分泌的变化可作为GDM诊断、预后和治疗的新标志物。本文就外泌体miRNA和循环miRNA在GDM中的作用作一综述。我们发现某些miRNAs的表达变化可用于GDM的诊断。外泌体miRNA靶向代谢途径，导致胰岛素抵抗。我们还强调了miRNAs和外泌体miRNAs作为诊断或治疗药物的生物标志物的潜力。
Gestational diabetes mellitus (GDM) is defined as glucose intolerance that occurs during the second or third trimester of pregnancy. As the incidence of GDM rises, so does the risk of maternal and fetal complications with short- and long-term consequences. As a result, early diagnosis and treatment of this condition are important to avoiding adverse pregnancy outcomes. Exosomes are tiny vesicles secreted by living cells which contain a variety of bioactive substances. They are released by cells to facilitate cell-to-cell communication and regulate a variety of biological processes such as cellular immune response, inflammatory response, and apoptosis, among others. Many studies have recently confirmed that changes in the expression and secretion of exosomal miRNAs can be used as novel markers for the diagnosis, prognosis, and treatment of GDM. In this review, we summarized the various roles of exosomal miRNAs and circulating miRNAs in GDM. We found that the changes in the expression of certain miRNAs could be used to diagnosing GDM. Exosomal miRNAs target metabolic pathways, resulting in insulin resistance. We also highlighted the potential for miRNAs and exosomal miRNAs to be used as biomarkers for diagnosis or therapeutic agents.