Sintering of calcium phosphates with a femtosecond pulsed laser for hard tissue engineering
Sintering of calcium phosphates with a femtosecond pulsed laser for hard tissue engineering
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DOI：
10.1016/j.matdes.2016.03.159
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发表时间：
2016-07-05
影响因子：
8.4
通讯作者：
Jha, A.
中科院分区：
文献类型：
--
作者：
Anastasiou, A. D.;Thomson, C. L.;Jha, A.
在硬组织上直接激光烧结可能为个性化医疗开辟新途径。为了最大限度地减少周围软组织的辐射损伤，需要在对组织和具有改进的光学特性的生物材料“安全”的波长下工作的激光器。在这项工作中，激光烧结被证明与使用超快，飞秒（100 fs）脉冲激光器在1045 nm的波长和两个现有的磷酸钙矿物（透钙磷石和羟基磷灰石），已被改善后掺杂铁（10摩尔%）。飞秒激光照射引起的Fe 3+掺杂透钙磷石和Fe 3+掺杂HAp样品转化为β-焦磷酸钙和钙铁磷酸盐，分别与同时的微观结构烧结和致密化的证据。在估计了样品表面的温度分布后，我们认为，距离辐照区500 μ m以上的软组织不会受到热损伤。这种新颖的激光加工提供了一种手段来控制相组成和完成的表面的形态。β-焦磷酸盐的多孔结构可能适合于通过支持成骨细胞活性而在骨再生中的应用，而致密的富含Fe 3+的钙-铁-磷酸盐可能有希望用于牙釉质修复等应用。(C)2016爱思唯尔有限公司版权所有
Direct laser sintering on hard tissues is likely to open new pathways for personalised medicine. To minimise irradiation damage of the surrounding soft tissues, lasers operating at wavelengths that are 'safe' for the tissues and biomaterials with improved optical properties are required. In this work laser sintering is demonstrated with the use of an ultrafast, femtosecond (100 fs) pulsed laser operating at a wavelength of 1045 nm and two existing calcium phosphate minerals (brushite and hydroxyapatite) which have been improved after doping with iron (10 mol%). Femtosecond laser irradiation caused transformation of the Fe3+-doped brushite and Fe3+-doped HAp samples into beta-calcium pyrophosphate and calcium-iron-phosphate, respectively, with simultaneous evidence for microstructural sintering and densification. After estimating the temperature profile at the surface of the samples we suggest that soft tissues over 500 mu m from the irradiated zone would be safe from thermal damage. This novel laser processing provides a means to control the phase constitution and the morphology of the finished surfaces. The porous structure of beta-pyrophosphate might be suitable for applications in bone regeneration by supporting osteogenic cell activity while, the densified Fe3+-rich calcium-iron-phosphate may be promising for applications like dental enamel restoration. (C) 2016 Elsevier Ltd. All rights reserved.