Centrosome composition and microtubule anchoring mechanisms
Centrosome composition and microtubule anchoring mechanisms
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DOI：
10.1016/s0955-0674(01)00290-3
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发表时间：
2002-02-01
影响因子：
7.5
通讯作者：
Bornens, M
中科院分区：
文献类型：
--
作者：
Bornens, M
动物细胞的中心体和真菌的纺锤体是微管的主要成核中心。最近的研究表明，它们组织微管阵列的能力依赖于对有核微管的锚定和释放的精心控制。虽然共同的分子机制可能涉及在这两种情况下，从动物细胞的中心体显示出相当大的复杂性和灵活性，这与简单的层状组织的纺锤体极体在真菌。中心粒对在控制动物细胞中中心体的结构稳定性和活性方面的作用现在变得越来越清楚。利用中心体或纺锤体的世代不对称性来控制细胞极性也是一个日益增长的主题。
Centrosomes of animal cells and spindle pole bodies of fungi are the major microtubule nucleating centers. Recent studies indicate that their capacity to organize microtubule arrays rests on elaborate control of the anchoring and release of the nucleated microtubules. Although common molecular mechanisms are likely to be involved in both cases, the centrosome from animal cells shows considerable complexity and flexibility, which contrasts with the simple laminar organization of spindle pole bodies in fungi. The role of the centriole pair in controlling both the structural stability and the activity of the centrosome in animal cells is now becoming clearer. The potential use of the generational asymmetry of centrosomes or spindle pole bodies for controlling cell polarity is also a growing theme.