A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
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DOI：
10.1182/blood-2006-07-038430
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发表时间：
2007-03-15
期刊：
影响因子：
20.3
通讯作者：
Barlogie, Bart
中科院分区：
文献类型：
--
作者：
Shaughnessy, John D.;Zhan, Fenghuang;Barlogie, Bart
为了从分子水平上定义高危疾病，我们对532例新诊断的多发性骨髓瘤（MM）患者的肿瘤细胞进行了微阵列分析，这些患者接受了2种不同的治疗方案。使用表达四分位数的对数秩检验，70个基因，30%定位于1号染色体（P
To molecularly define high-risk disease, we performed microarray analysis on tumor cells from 532 newly diagnosed patients with multiple myeloma (MM) treated on 2 separate protocols. Using log-rank tests of expression quartiles, 70 genes, 30% mapping to chromosome 1 (P