Quantitative two-dimensional photoacoustic tomography of osteoarthritis in the finger joints
Quantitative two-dimensional photoacoustic tomography of osteoarthritis in the finger joints
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DOI：
10.1364/oe.18.014359
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发表时间：
2010-07-05
期刊：
影响因子：
3.8
通讯作者：
Jiang, Huabei
中科院分区：
文献类型：
--
作者：
Xiao, Jiaying;Yao, Lei;Jiang, Huabei
我们提出的第一次在体内实验证据表明，定量光声断层扫描（qPAT）有可能检测骨关节炎（OA）的手指关节。在这项初步研究中，2名OA患者和4名健康志愿者被招募，他们的远端指间关节（DIP）的PAT扫描仪进行了光声检查。组织吸收系数图像的所有检查关节，这是无法从传统的PAT，恢复使用我们的有限元为基础的qPAT方法。恢复的定量光声图像显示OA和正常关节之间的关节腔（软骨和滑液）的组织吸收系数的显着差异。(C)2010年美国光学学会
We present for the first time in vivo experimental evidence that quantitative photoacoustic tomography (qPAT) has the potential to detect osteoarthritis (OA) in the finger joints. In this pilot study, 2 OA patients and 4 healthy volunteers were enrolled, and their distal interphalangeal (DIP) joints were examined photoacoustically by a PAT scanner. Tissue absorption coefficient images of all the examined joints, which were unavailable from the conventional PAT, were recovered using our finite element based qPAT approach. The recovered quantitative photoacoustic images revealed significant differences in the tissue absorption coefficient of the joint cavity (cartilage and synovial fluid) between the OA and normal joints. (C) 2010 Optical Society of America