ANALYSIS OF ULTRAFILTRATION AND MASS-TRANSFER IN A BIOARTIFICIAL PANCREAS
ANALYSIS OF ULTRAFILTRATION AND MASS-TRANSFER IN A BIOARTIFICIAL PANCREAS
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DOI：
10.1115/1.3108400
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发表时间：
1988-02-01
影响因子：
1.7
通讯作者：
NOTELET, D
中科院分区：
文献类型：
--
作者：
JAFFRIN, MY;REACH, G;NOTELET, D
生物人工胰腺是一种可植入的装置，其中含有胰岛素分泌细胞（朗格汉斯胰岛），通过半透膜与循环血液隔离以避免排斥。本文描述了这种装置的操作，并评估了扩散和超滤对葡萄糖和胰岛素传质的各自贡献。结果表明，沿着血液通道的压降在通道的前半部分产生朝向胰岛室的超滤通量，随后在后半部分产生从胰岛到血液的相反方向的相等通量。进行传质分析以获得最佳几何形状，其中 U 形血液通道紧密围绕由折叠平板膜形成的非常薄的胰岛室。开发了该装置的胰岛素释放的完整模型，并将其与大鼠胰岛获得的体外数据进行比较。血液透析中使用的聚丙烯腈膜可实现令人满意的动力学。但模型表明，膜水力渗透率应增加 10 倍才能显着提高性能。
A bioartificial pancreas is an implantable device which contains insulin secreting cells (Langerhans islets), separated from the circulating blood by a semi-permeable membrane to avoid rejection. This paper describes the operation of such a device and evaluates the respective contributions of diffusion and ultrafiltration to the glucose and insulin mass transfer. It is shown that the pressure drop along the blood channel produces across the first half of the channel an ultrafiltration flux toward the islet compartment followed in the second half by an equal flux in reverse direction from islets to blood. The mass transfer analysis is carried out for an optimal geometry in which a U-shaped blood channel surrounds closely a very thin islet compartment formed by a folded flat membrane. A complete model of insulin release by this device is developed and is compared with in vitro data obtained with rats islets. Satisfactory kinetics is achieved with a polyacrylonitrile membrane used in hemodialysis. But the model shows that the membrane hydraulic permeability should be increased by a factor of 10 to significantly improve the performance.