Auditory brainstem response differences in diabetic and non-diabetic veterans
Auditory brainstem response differences in diabetic and non-diabetic veterans
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DOI：
10.3766/jaaa.18.10.5
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发表时间：
2007-11-01
影响因子：
1.2
通讯作者：
Fausti, Stephen
中科院分区：
文献类型：
--
作者：
Vaughan, Nancy;James, Kenneth;Fausti, Stephen
许多研究发现，与非糖尿病对照组相比，糖尿病患者的听觉脑干潜伏期有统计学意义上的延迟。然而，导致糖尿病和非糖尿病患者潜伏期差异的机制在不同的研究中有所不同，而且潜伏期差异虽然显著，但很小。在这项为期5年的前瞻性研究中，来自波特兰退伍军人事务医疗中心的416名非糖尿病退伍军人和375名糖尿病退伍军人进行了听觉脑干反应测试，作为一项更大研究的一部分。糖尿病患者右耳III波和V波潜伏期明显延迟，双耳I-III波和I-V波潜伏期明显延长。刺激极性差异产生的结果略有不同。在考虑听力损失和年龄后，所有糖尿病相关临床特征与受试者组之间的潜伏期差异无关。计算效应量并讨论这些差异的临床意义。
A number of studies have found statistically significant delays in auditory brainstem latencies of patients with diabetes compared with non-diabetic controls. However, the mechanisms ascribed as responsible for the latency differences between diabetic and non-diabetic patients vary among studies, and the latency differences, while significant, are small. In this 5-year prospective study, auditory brainstem response testing was conducted with 416 nondiabetic and 375 diabetic veterans from the Portland Veterans Affairs Medical Center as part of a larger study. Patients with diabetes had significantly delayed latencies of Wave III and V in the right ear and significantly prolonged interpeak I-III and I-V latencies in both ears. Stimulus polarity difference yielded slightly different results. None of the diabetes-related clinical characteristics were associated with the latency differences between the Subject groups after accounting for hearing loss and age. Effect size was calculated and clinical significance of these differences is discussed.