Cornea biomechanical characteristics and their correlates with refractive error in Singaporean children
Cornea biomechanical characteristics and their correlates with refractive error in Singaporean children
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DOI：
10.1167/iovs.07-1670
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发表时间：
2008-09-01
影响因子：
4.4
通讯作者：
Saw, Seang-Mei
中科院分区：
文献类型：
--
作者：
Lim, Laurence;Gazzard, Gus;Saw, Seang-Mei
目的。旨在确定新加坡儿童使用 Reichert 眼反应分析仪 (ORA) 测量的角膜生物力学参数，并评估其与屈光不正和生物测量之间可能的相关性。方法。这是一项针对新加坡近视危险因素队列研究 (SCORM) 的 271 名受试者进行的横断面研究。使用 ORA 测量角膜滞后 (CH)、角膜阻力因子 (CRF)、中央角膜厚度 (CCT) 和角膜补偿眼压 (IOPcc)。使用自动角膜屈光仪评估球面等效屈光度，并通过接触式超声 A 扫描生物测定法评估眼轴长度。测量身高、体重和血压。结果。研究人群的平均年龄为13.97+/-0.89岁，性别分布几乎相等（138名男孩，占50.9%），其中大多数是中国人（186名受试者，68.6%）。平均 (+/- SD) CH 和 CRF 分别为 11.78 +/- 1.55（范围，6.93 - 16.53）和 11.81 +/- 1.71（范围，7.83 - 16.83）mm Hg。 CH 和 CRF 不随年龄（P = 0.24；0.61）、性别（P = 0.21；0.08）或种族（P = 0.23；0.36）而显着变化。 CH 和 CRF 不随近视状态（P = 0.79；0.83）或眼轴长度（Pearson 相关系数 [r] = -0.11 和 -0.05，P = 0.08 和 0.40）而变化。以 CH、CRF 或 CCT 作为因变量，以年龄、性别、种族、体重、IOPcc、CCT、SE 屈光和角膜曲率作为协变量进行多变量分析。 CH 与 IOP（回归系数 β = -0.22 [95% 置信区间 = -0.27 至 -0.17]）、CCT（β = 0.03 [0.02 - 0.03]）和角膜曲率（β = -1.13 [-2.08 至 -0.19]）显着相关。 CRF 与 IOP、CCT 和角膜曲率显着相关（β 值分别为 0.08 [0.02 - 0.14]、0.03 [0.03 - 0.04] 和 -1.39 [-2.54 至 -0.23]）。与华人相比，预测 CCT 下降的唯一因素是马来人或印度人种（P = 0.03 和 < 0.001）。结论。我们对新加坡儿童的研究中的 CH 和 CRF 值略高于成人研究。 CH 和 CRF 与屈光不正或眼轴长度无关。角膜较平坦与 CH 和 CRF 读数较低相关。
PURPOSE. To determine corneal biomechanical parameters measured with the Reichert Ocular Response Analyser (ORA) in Singaporean children, and to assess their possible correlations with refractive error and biometry. METHODS. This was a cross-sectional study of 271 subjects from the Singapore Cohort Study of Risk Factors for Myopia (SCORM). Corneal hysteresis (CH), corneal resistance factor (CRF), central corneal thickness (CCT), and cornea-compensated intraocular pressure (IOPcc) were measured with the ORA. Spherical equivalent refraction was assessed with an autokeratorefractometer and axial length by contact ultrasound A-scan biometry. Height, weight, and blood pressure were measured.RESULTS. The mean age of the study population was 13.97 +/- 0.89 years, the distribution of the sexes was almost equal (138 boys, 50.9%), and most were Chinese (186 subjects, 68.6%). The mean (+/- SD) CH and CRF were 11.78 +/- 1.55 (range, 6.93 - 16.53) and 11.81 +/- 1.71 (range, 7.83 - 16.83) mm Hg. CH and CRF did not vary significantly with age (P = 0.24; 0.61), sex (P = 0.21; 0.08), or race (P = 0.23; 0.36). CH and CRF did not vary with myopia status (P = 0.79; 0.83) or axial length (Pearson correlation coefficient [r] = -0.11 and -0.05, P = 0.08 and 0.40). Multivariate analyses were performed with CH, CRF, or CCT as the dependent variable and age, sex, race, weight, IOPcc, CCT, SE refraction, and corneal curvature as covariates. CH was significantly associated with IOP (regression coefficients [beta] = -0.22 [95% confidence interval = -0.27 to -0.17]), CCT (beta = 0.03 [0.02 - 0.03]) and corneal curvature (beta = -1.13 [-2.08 to -0.19]). CRF was significantly associated with IOP, CCT, and corneal curvature (beta = 0.08 [0.02 - 0.14]; 0.03 [0.03 - 0.04], and -1.39 [-2.54 to -0.23], respectively). The only factor that was predictive of decreased CCT was Malay or Indian race (P = 0.03 and < 0.001), compared with Chinese.CONCLUSIONS. The CH and CRF values in our study on Singaporean children are slightly higher than in adult studies. CH and CRF are not associated with refractive error or axial length. Flatter corneas are associated with lower CH and CRF readings.