DECAPENTAPLEGIC TRANSCRIPTS ARE LOCALIZED ALONG THE DORSAL VENTRAL AXIS OF THE DROSOPHILA EMBRYO
DECAPENTAPLEGIC TRANSCRIPTS ARE LOCALIZED ALONG THE DORSAL VENTRAL AXIS OF THE DROSOPHILA EMBRYO
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DOI：
10.1002/j.1460-2075.1987.tb02574.x
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发表时间：
1987-09-01
期刊：
影响因子：
11.4
通讯作者：
GELBART, WM
中科院分区：
文献类型：
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作者：
STJOHNSTON, RD;GELBART, WM
黑腹果蝇（Drosophila melanogaster，dpp）的十肢麻痹基因与哺乳动物生长因子的TGF-β家族相关。为了研究DPP在早期发育中的作用，我们检测了DPP转录本在胚胎中表达的空间模式。转录首先被检测到沿着背侧的早期合胞胚盘胚胎。在胚带伸长期间，该基因在将产生背表皮的区域中表达。由于dppHin胚胎缺乏背侧表皮的所有衍生物，这表明dpp在发育早期需要用于确定背侧位置值。在胚胎发生的后期，外胚层中的表达发生变化，产生沿胚胎长度沿着前后延伸的两条细条。这种表达模式可能涉及沿着背腹轴的进一步细分。在这个阶段，转录也可以检测到内脏中胚层，前肠和后肠的离散部分。
The decapentaplegic gene of Drosophila melanogaster (dpp) is related to the TGF‐beta family of mammalian growth factors. In order to investigate the role of dpp during early development we examined the spatial pattern of expression of dpp transcripts in embryos. Transcription is first detected along the dorsal side of early syncytial blastoderm embryos. During germ band elongation, the gene is expressed in the region which will give rise to the dorsal epidermis. Since dppHin‐embryos lack all derivatives of the dorsal epidermis, this suggests that dpp is required early in development for the determination of dorsal positional values. Later in embryogenesis, expression in the ectoderm changes to give two thin stripes running anterior‐posteriorly along the length of the embryo. This pattern of expression may be involved in further subdivisions along the dorsal‐ventral axis. At this stage, transcription can also be detected in discrete parts of the visceral mesoderm, foregut and hindgut.