Nationwide survey of Japanese breast oncology and reproductive endocrinology departments about the impact of breast cancer treatment on fertility
Nationwide survey of Japanese breast oncology and reproductive endocrinology departments about the impact of breast cancer treatment on fertility
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DOI：
10.1111/jog.14469
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发表时间：
2020-10
影响因子：
1.6
通讯作者：
R. Yamazaki;M. Ono;T. Sugie;M. Inokuchi;S. Ishikawa;Takashi Iizuka;Sakiko Masumoto;S. Myojo;Soko Uchida;A. Horie;Toshiya Matsuzaki
中科院分区：
文献类型：
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作者：
R. Yamazaki;M. Ono;T. Sugie;M. Inokuchi;S. Ishikawa;Takashi Iizuka;Sakiko Masumoto;S. Myojo;Soko Uchida;A. Horie;Toshiya Matsuzaki
本研究的目的是评估乳腺癌治疗对生殖潜能的影响。我们在全国范围内对乳腺肿瘤学和生殖内分泌与不孕症（REI）部门进行了调查，使用问卷来评估乳腺癌治疗对生育能力的影响。我们收到312个乳腺肿瘤科室（有效率为31.9%）和541个REI科室（有效率为50.9%）的反馈。乳腺肿瘤科报告的实现妊娠的最常见方法是自然人工授精（69.6%），其次是辅助生殖技术（15.6%）和宫内人工授精（IUI; 14.8%）。REI部门报告的最常见的妊娠方法是常规体外受精和/或胞浆内单精子注射（51.0%），其次是自然人工授精（40.0%）和人工授精（8.0%）。乳腺癌治疗后在REI科室接受不孕症治疗的患者总体妊娠率为39.0%。根据乳腺肿瘤科的数据，大量接受过乳腺癌治疗的患者主要是通过自然人工授精受孕。另一方面，因自然授精不孕而就诊的患者中，61.0%的患者即使接受了不孕不育专科的专门知识治疗也没有怀孕。
The purpose of this study is to assess the impact of breast cancer treatment on the reproductive potential. We conducted a nationwide survey of breast oncology and reproductive endocrinology and infertility (REI) departments using a questionnaire designed to assess the impact of breast cancer treatment on fertility. We received responses from 312 breast oncology departments (response rate, 31.9%) and 541 REI departments (response rate, 50.9%). The most common method of achieving pregnancy reported by breast oncology departments was natural insemination (69.6%), followed by assisted reproductive technology ( 15.6%) and intrauterine insemination (IUI; 14.8%). The most common method of achieving pregnancy reported by REI departments was conventional in vitro fertilization and/or intracytoplasmic sperm injection (51.0%), followed by natural insemination with or without ovulation induction (40.0%) and IUI (8.0%). The overall pregnancy rate for patients who underwent treatment for infertility at REI departments after breast cancer treatment was 39.0%. Vast patients who experienced breast cancer treatments conceived mainly by natural insemination based on the data from breast oncology departments. On the other hand, 61.0% of the patients who visited REI departments presumably due to infertility by natural insemination did not conceive even by infertility treatments with exclusive knowledge in REI departments.