The role of inferior parietal cortex and fornix in route following and topographic orientation in cynomolgus monkeys
The role of inferior parietal cortex and fornix in route following and topographic orientation in cynomolgus monkeys
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DOI：
10.1016/0166-4328(96)00177-5
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发表时间：
1996-02-01
影响因子：
2.7
通讯作者：
Latto, R
中科院分区：
文献类型：
--
作者：
Barrow, CJ;Latto, R
在单一种属（食蟹猴）内并使用传统（固定入口和出口）全身迷宫中的单一路径模式，比较了下顶叶皮质病变（区域7a/PG）和穹窿双侧横断的影响。实验1表明，区域7a/PG，而不是穹窿病变损害术后保持路线运行。实验2评估的贡献，视觉线索和本体/动觉的指导路线运行，并表明，在nonlesioned猴子路线运行的影响，在不同程度上由本体的指导，视觉迷宫外的房间线索和视觉迷宫刺激。迷宫性能的术后评估，包括错误模式，再训练和误触（实验1），表明，在顶骨组的猴子没有地形定向障碍，并没有空间的长期记忆缺陷，但它是他们的困难响应本地空间线索，最初损害路线运行。线索使用的调查（实验2）也表明，局部空间线索的顶叶组的敏感性，他们通过一个新的开始位置时，迷宫刺激和额外的迷宫线索之间的关系发生了变化，进入显着受损。穹窿组没有表现出逆行的长期记忆缺陷的路线运行（实验1）。然而，在实验2中，一个新的目标位置学习，穹窿组没有表现出顺行记忆缺陷。
The effects of inferior parietal cortex lesions (Area 7a/PG) and bilateral transection of the fornix were compared within a single species (cynomolgus monkeys) and using a single paradigm of route running in a traditional (fixed entry and exit) whole-body maze. Experiment 1 showed that Area 7a/PG but not fornix lesions impaired post-operative retention of route running. Experiment 2 assessed the contribution of visual cues and proprioceptive/kinaesthetic guidance to route running and showed that in nonlesioned monkeys route running was influenced to varying degrees by proprioceptive guidance, visual extra-maze room cues and visual maze stimuli. Post-operative assessment of maze performance, including error patterns, retraining and misreaching (Experiment 1), suggested that monkeys in the Parietal Group were not topographically disoriented and did not have a spatial long-term memory deficit, but it was their difficulty responding to local spatial cues which initially impaired route running. Investigation of cue use (Experiment 2) also showed the sensitivity of the Parietal Group to local spatial cues; they were significantly impaired on entry through a new start position when the relationship between maze stimuli and extra-maze cues was changed. The Fornix Group showed no retrograde long-term memory deficit for route-running (Experiment 1). However, in Experiment 2, where a new goal position was learnt, the Fornix Group did show an anterograde memory deficit.