Activation of histamine H3 receptors inhibits renal noradrenergic neurotransmission in anesthetized dogs.
Activation of histamine H3 receptors inhibits renal noradrenergic neurotransmission in anesthetized dogs.
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组胺 H3 受体的激活抑制麻醉犬的肾脏去甲肾上腺素能神经传递。
DOI：
10.1152/ajpregu.2001.280.5.r1450
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Yasuo Matsumura
中科院分区：
文献类型：
--
作者：
Tomoyuki Yamasaki;I. Tamai;Yasuo Matsumura
为探讨组胺H（3）受体在肾去甲肾上腺素能神经传递中的可能作用，观察了选择性H（3）受体激动剂（R）α-甲基组胺（R-HA）和选择性H（3）受体拮抗剂硫代哌丁胺（Thiop）对肾神经刺激（RNS）引起的肾功能变化和去甲肾上腺素（NE）溢出的影响。RNS（0.5-2.0 Hz）可显著减少尿流量和尿钠排泄，增加NE溢出率（NEOR），而不影响肾血流动力学。当静脉输注R-HA（1 μ g x kg（-1）x min（-1））时，平均动脉压和心率显著降低，并且有降低尿流量和尿钠排泄的基础值的趋势。在R-HA输注过程中，RNS诱导的抗利尿作用和NEOR增加显著减弱。Thiop输注（5 μ g x kg（-1）x min（-1））不影响基础血流动力学和排泄参数。Thiop输注引起RNS诱导的抗利尿作用和NEOR增加，与基础条件相似。当R-HA与Thiop输注同时给药时，R-HA未能减弱RNS诱导的抗利尿作用和NEOR增加。然而，在pyrilamine（一种选择性H1受体拮抗剂）或西咪替丁（一种选择性H2受体拮抗剂）输液的存在下，R-HA减弱了RNS诱导的行动，类似于没有这些拮抗剂的情况。因此，可能位于肾脏去甲肾上腺素能神经末梢上的功能性组胺H3受体可能发挥肾脏去甲肾上腺素能神经传递抑制性调节剂的作用。
To investigate the possible involvement of histamine H(3) receptors in renal noradrenergic neurotransmission, effects of (R)alpha-methylhistamine (R-HA), a selective H3-receptor agonist, and thioperamide (Thiop), a selective H3-receptor antagonist, on renal nerve stimulation (RNS)-induced changes in renal function and norepinephrine (NE) overflow in anesthetized dogs were examined. RNS (0.5-2.0 Hz) produced significant decreases in urine flow and urinary sodium excretion and increases in NE overflow rate (NEOR), without affecting renal hemodynamics. When R-HA (1 microg x kg(-1) x min(-1)) was infused intravenously, mean arterial pressure and heart rate were significantly decreased, and there was a tendency to reduce basal values of urine flow and urinary sodium excretion. During R-HA infusion, RNS-induced antidiuretic action and increases in NEOR were markedly attenuated. Thiop infusion (5 microg x kg(-1) x min(-1)) did not affect basal hemodynamic and excretory parameters. Thiop infusion caused RNS-induced antidiuretic action and increases in NEOR similar to the basal condition. When R-HA was administered concomitantly with Thiop infusion, R-HA failed to attenuate the RNS-induced antidiuretic action and increases in NEOR. However, in the presence of pyrilamine (a selective H1-receptor antagonist) or cimetidine (a selective H2-receptor antagonist) infusion, R-HA attenuated the RNS-induced actions, similarly to the case without these antagonists. Thus functional histamine H3 receptors, possibly located on renal noradrenergic nerve endings, may play the role of inhibitory modulators of renal noradrenergic neurotransmission.
揭示心肌缺血中激活的组胺 H3 受体：它们作为胞吐去甲肾上腺素释放调节剂的作用。
DOI：
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发表时间：
1994
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Imamura,M;Poli,E;Omoniyi,AT;Levi,R
通讯作者：
Levi,R
DOI：
--
发表时间：
1994-04
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
M. Endou;E. Poli;R. Levi
通讯作者：
M. Endou;E. Poli;R. Levi
在人类长期心肌缺血模型中，组胺 H3 受体的激活抑制载体介导的去甲肾上腺素释放。
DOI：
--
发表时间：
1997
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Hatta,E;Yasuda,K;Levi,R
通讯作者：
Levi,R