TLR2-Dependent Inflammatory Response to Porphyromonas gingivalis Is MyD88 Independent, whereas MyD88 Is Required To Clear Infection
TLR2-Dependent Inflammatory Response to Porphyromonas gingivalis Is MyD88 Independent, whereas MyD88 Is Required To Clear Infection
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DOI：
10.4049/jimmunol.0900378
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发表时间：
2010-02-01
影响因子：
4.4
通讯作者：
Nussbaum, Gabriel
中科院分区：
文献类型：
--
作者：
Burns, Elia;Eliyahu, Tal;Nussbaum, Gabriel
牙龈卟啉单胞菌是一种革兰氏阴性厌氧菌，被认为是一种主要的牙周病原体。TLR2在体内对牙龈P感染的应答中起核心作用。如果没有它，炎症反应很弱；然而，与野生型小鼠相比，细菌被迅速清除。我们研究了TLR接头蛋白MyD88和含有TLR/ il - 1r结构域的接头诱导ifn - β在体内对牙龈P的炎症反应和清除细菌感染的能力中的作用。牙龈P感染的促炎细胞因子的产生依赖于TLR2，但不需要MyD88或含有TLR/ il - 1r结构域的适配器诱导ifn - β。相反，细胞内有毒氧的产生和牙龈P感染的最终清除主要依赖于MyD88，而不依赖于TLR2。因此，强大的细胞因子生产和细菌清除是独立的事件介导不同的信号通路感染牙龈假单胞菌。免疫学杂志，2010,18(4):1455-1462。
Porphyromonas gingivalis is a Gram-negative anaerobe considered to be a major periodontal pathogen. TLR2 plays a central role in the response to P gingivalis infection in vivo. In its absence there is a weak inflammatory response; however, bacteria are cleared rapidly compared with wild-type mice. We examined the role of the TLR adaptor proteins MyD88 and TLR/IL-1R-domain-containing adaptor-inducing IFN-beta in the inflammatory response to P gingivalis in vivo and in the ability to clear the bacterial infection. Proinflammatory cytokine production in response to P gingivalis infection depends on TLR2, but it does not require MyD88 or TLR/IL-1R-domain-containing adaptor-inducing IFN-beta. In contrast, the generation of intracellular toxic oxygen species and the ultimate clearance of P gingivalis infection depend critically on MyD88, independent of TLR2. Thus, robust cytokine production and bacterial clearance are independent events mediated by distinct signaling pathways following infection with P. gingivalis. The Journal of Immunology, 2010, 184: 1455-1462.