The Association between Diet and Serum Concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition
The Association between Diet and Serum Concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition
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DOI：
10.1158/1055-9965.epi-08-0781
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发表时间：
2009-05-01
影响因子：
3.8
通讯作者：
Kaaks, Rudolf
中科院分区：
文献类型：
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作者：
Crowe, Francesca L.;Key, Timothy J.;Kaaks, Rudolf
胰岛素样生长因子I（IGF-I）和IGF结合蛋白（IGFBP）的循环浓度与几种癌症的风险有关。IGF-I和IGFBPs的饮食相关性尚未完全确定。本研究的目的是评估饮食摄入量与IGF-I，IGFBP-1，IGFBP-2和IGFBP-3血清浓度之间的关系，对参加欧洲癌症和营养前瞻性调查的4，731名男性和女性进行横断面分析。使用特定国家经过验证的饮食问卷评估饮食。测定血清IGF-I、IGFBP-1、IGFBP-2和IGFBP-3浓度，并采用多元线性回归分析评估饮食与IGF-I和IGFBPs之间的相关性，调整性别、年龄、体重指数、吸烟状况、酒精和能量摄入。总蛋白质、乳蛋白质和钙摄入量的每一个I SD增量的增加分别与IGF-I浓度的2.5%、2.4%和3.3%的增加相关（趋势P
Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple linear regression adjusting for sex, age, body mass index, smoking status, and alcohol and energy intake. Each I SD increment increase in total and dairy protein and calcium intake was associated with an increase in IGF-I concentration of 2.5%, 2.4%, and 3.3%, respectively (P for trend