Computational method to assign microbial genes to pathways
Computational method to assign microbial genes to pathways
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DOI：
10.1002/jcb.10071
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发表时间：
2001-01-01
影响因子：
4
通讯作者：
Bowers, P
中科院分区：
文献类型：
--
作者：
Pellegrini, M;Thompson, M;Bowers, P
我们提出的技术，挖掘完全测序的微生物基因组基因之间的功能关系。我们发现，由四种技术之一相关的基因更有可能属于相同的细胞通路。此外，我们证明了一个未表征的基因的途径可以推断出其功能相关的合作伙伴。因此，我们现在能够将细菌内的大多数基因分配给细胞途径。(C)2002 Wiley-Liss，Inc.
We present techniques that mine fully sequenced microbial genomes for functional relationships between genes. We show that genes related by one of four techniques are more likely to belong to the same cellular pathways. Furthermore, we demonstrate that the pathway of an uncharacterized gene may be inferred from those of its functionally related partners. Therefore, we are now able to assign most of the genes within bacteria to cellular pathways. (C) 2002 Wiley-Liss, Inc.