Nomogram for deciding adjuvant treatment after surgery for oral cavity squamous cell carcinoma
Nomogram for deciding adjuvant treatment after surgery for oral cavity squamous cell carcinoma
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DOI：
10.1002/hed.20879
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发表时间：
2008-10-01
影响因子：
2.9
通讯作者：
Kattan, Michael W.
中科院分区：
文献类型：
--
作者：
Gross, Neil D.;Patel, Snehal G.;Kattan, Michael W.
背景资料。口腔鳞状细胞癌(OCSCC)术后适当辅助治疗的应用是建立在准确的患者危险分层的基础上的。从在纪念斯隆-凯特琳癌症中心(MSKCC)接受治疗的590名口腔鳞癌患者的队列中构建了一个用于评估OCSCC治疗后局部无复发生存率(LRFS)的诺模图。对在巴西圣保罗癌症控制医院(HACC)接受治疗的417名口腔鳞状细胞癌患者进行了验证。尽管MSKCC和HACC队列之间有显著差异，但诺模图能够预测OCSCC的LRF，一致性指数为0.693。进一步的统计分析表明，诺模图得到了很好的校准。这个初步的诺模图是第一个开发和外部验证的预后模型，用于预测单个OCSCC患者治疗后发生LRFS的可能性，并可能对决定辅助治疗具有实用价值。(C)2008年威利期刊公司。
Background. The application of appropriate adjuvant treatment after surgery for oral cavity squamous cell carcinoma (OCSCC) is predicated on accurate patient risk stratification.Methods. A nomogram for estimating locoregional recurrence-free survival (LRFS) after treatment of OCSCC was constructed from a cohort of 590 patients with OCSCC who were treated at Memorial Sloan-Kettering Cancer Center (MSKCC). The nomogram was validated using a series of 417 patients with OCSCC who were treated at Hospital do Cancer AC Camargo (HACC) in So Paulo, Brazil.Results. Despite significant differences between the MSKCC and HACC cohorts, the nomogram was able to predict LRFS from OCSCC with a concordance index of 0.693. Further statistical analysis showed that the nomogram was well calibrated.Conclusions. This preliminary nomogram is the first prognostic model developed and externally validated to predict the likelihood of LRFS after treatment for an individual patient with OCSCC and may have practical utility for deciding adjuvant treatment. (C) 2008 Wiley Periodicals, Inc.