A Case of Seronegative Limbic Encephalitis with Multiple Sclerosis: A Possible Overlapping Syndrome.
A Case of Seronegative Limbic Encephalitis with Multiple Sclerosis: A Possible Overlapping Syndrome.
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伴有多发性硬化症的血清神经缘脑炎病例：可能重叠的综合征。
DOI：
10.12659/ajcr.901391
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发表时间：
2017-01-18
期刊：
影响因子：
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通讯作者：
Türkoğlu R
中科院分区：
文献类型：
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作者：
Karaaslan Z;Mercan Ö;Tüzün E;Mısırlı H;Türkoğlu R
患者：女性，45岁最终诊断：自身免疫性脑炎症状：记忆丧失•精神状态改变•快感缺乏药物：甲基强的松龙•免疫球蛋白临床程序：免疫治疗专业：神经病学罕见的疾病或病理共存自身免疫性脑炎可能同时存在于自身免疫性脱髓鞘疾病患者中。我们报告一例45岁女性多发性硬化症（MS）患者，表现为急性发作的短期记忆丧失，精神状态改变，脑脊液（CSF）炎症性发现和左颞叶MRI病变。大量的神经自身抗体检测结果为阴性。神经心理症状对免疫治疗反应迅速，但对照MRI显示左侧海马萎缩。最近的几篇关于自身免疫性脑炎和多发性硬化症同时出现的报道提示了这些疾病的共同机制。由于自身免疫性脑炎和MS具有某些共同的脑脊液和神经影像学表现，因此需要增加对重叠的自身免疫性脑疾病的了解，以避免误诊，特别是在抗体阴性的自身免疫性脑炎病例中。
Patient: Female, 45 Final Diagnosis: Autoimmune encephalitis Symptoms: Memory loss • altered mental status • anhedonia Medication: Methylprednisolone • immunoglobulin Clinical Procedure: Immunotherapy Specialty: Neurology Rare co-existance of disease or pathology Autoimmune encephalitis might coexist in patients with autoimmune demyelinating disorders. We report on a case of a 45-year-old female multiple sclerosis (MS) patient presenting with acute onset short-term memory loss, altered mental status, inflammatory cerebrospinal fluid (CSF) findings and an MRI lesion on the left temporal lobe. An extensive panel for neuronal autoantibodies proved negative. Neuropsychological symptoms gave a prompt response to immunotherapy but nevertheless control MRI showed left hippocampal atrophy. Several recent reports of concurrent emergence of autoimmune encephalitis and MS suggest a common mechanism for these disorders. Since autoimmune encephalitis and MS share certain common CSF and neuroimaging findings, an increased understanding of overlapping autoimmune brain disorders is required to avoid mis-diagnosis especially in antibody negative autoimmune encephalitis cases.