DIFFERENTIATION OF DELTA AND MU OPIATE RECEPTOR LOCALIZATIONS BY LIGHT MICROSCOPIC AUTORADIOGRAPHY
DIFFERENTIATION OF DELTA AND MU OPIATE RECEPTOR LOCALIZATIONS BY LIGHT MICROSCOPIC AUTORADIOGRAPHY
复制标题
DOI：
10.1073/pnas.77.10.6239
复制
发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
YOUNG, WS
中科院分区：
文献类型：
--
作者：
GOODMAN, RR;SNYDER, SH;YOUNG, WS
观察到在大鼠脑中不同定位的阿片受体的离散群体[2]。吗啡样（μ）由125 I-标记的[D-Ala-2 MePhe 4 Met（O）5-ol]脑啡肽标记的δ受体选择性地集中在大脑皮层的层IV、某些丘脑核和导水管周围灰质中，而δ受体则集中在大脑皮层的层IV、某些丘脑核和导水管周围灰质中。125 I标记的[D-Ala 2D-Leu 5]脑啡肽受体分布较分散，在大脑皮质、纹状体、杏仁核和嗅结节中密度较高。由于它们的定位的相似性，提出μ。和δ受体分别是[Met]-和[Leu]脑啡肽神经元的生理受体。这些分布反映了归因于μ的不同生理功能。和δ受体，因此代表[Met]-和[Leu]脑啡肽神经元的离散功能。
Discrete populations [2] of opiate receptors that are differently localized in rat brain were observed. Morphine-like (.mu.) receptors, labeled by 125I-labeled [D-Ala-2MePhe4Met(O)5-ol]enkephalin, are concentrated selectively in lamina IV of the cerebral cortex, certain thalamic nuclei and the periaqueductal gray, while .delta. receptors, labeled by 125I-labeled [D-Ala2D-Leu5]enkephalin, are more diffused, having high densities in cerebral cortex, corpus striatum, amygdala and olfactory tubercle. Because of similarities in their localizations, it was proposed that .mu. and .delta. receptors are, respectively, the physiologic receptors for [Met]- and [Leu]enkephalin neurons. These distributions reflect the different physiological functions attributed to .mu. and .delta. receptors and thus represent discrete functions of [Met]- and [Leu]enkephalin neurons.