INTERNAL CAPSULE STROKE IN THE COMMON MARMOSET
INTERNAL CAPSULE STROKE IN THE COMMON MARMOSET
复制标题
DOI：
10.1016/j.neuroscience.2014.10.015
复制
发表时间：
2015-01-22
期刊：
影响因子：
3.3
通讯作者：
Seki, K.
中科院分区：
文献类型：
--
作者：
Puentes, S.;Kaido, T.;Seki, K.
脑卒中后白色物质损害与运动功能障碍直接相关。然而，WM损伤机制及其与运动障碍的关系仍然知之甚少。在人类中，脉络膜前动脉（AChA）冲洗内囊（IC），该区域的卒中可诱导孤立的运动障碍。本研究的目的是分析是否AChA闭塞可以损害IC在绒猴。用彩色乳胶灌注法观察了绒猴脑的血管分布，发现其与人脑解剖结构高度相似。接下来，开发了一种电凝AChA的新方法，慢性实验显示，在磁共振成像（MRI）扫描（第4天）和组织学（第11天）上，梗死损害了IC。行为分析使用以前开发的神经评分和我们自己的评分方法进行。绒猴表现出评分下降，在AChA电凝后第10天仍然明显。我们开发了一种新的方法，能够诱导损害的绒猴IC，可能是有用的详细研究WM损伤和行为变化后，中风的非人灵长类动物。(C)2014年IBRO。由爱思唯尔有限公司出版。保留所有权利。
White matter (WM) impairment and motor deficit after stroke are directly related. However, WM injury mechanisms and their relation to motor disturbances are still poorly understood. In humans, the anterior choroidal artery (AChA) irrigates the internal capsule (IC), and stroke to this region can induce isolated motor impairment. The goal of this study was to analyze whether AChA occlusion can injure the IC in the marmoset monkey. The vascular distribution of the marmoset brain was examined by colored latex perfusion and revealed high resemblance to the human brain anatomy. Next, a new approach to electrocoagulate the AChA was developed and chronic experiments showed infarction compromising the IC on magnetic resonance imaging (MRI) scanning (day 4) and histology (day 11). Behavioral analysis was performed using a neurologic score previously developed and our own scoring method. Marmosets showed a decreased score that was still evident at day 10 after AChA electrocoagulation. We developed a new approach able to induce damage to the marmoset IC that may be useful for the detailed study of WM impairment and behavioral changes after stroke in the nonhuman primate. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.