Primary renal diffuse large B-Cell lymphoma causing haemodialysis-dependent nephromegaly in a child.
Primary renal diffuse large B-Cell lymphoma causing haemodialysis-dependent nephromegaly in a child.
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原发性肾弥漫性大 B 细胞淋巴瘤导致儿童血液透析依赖性肾肿大。
DOI：
10.1136/bcr-2018-226328
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发表时间：
2018
期刊：
影响因子：
0.9
通讯作者：
South,AndrewMichael
中科院分区：
文献类型：
--
作者：
South,AndrewMichael
一名4岁男童出现疲倦症状，并被发现严重肾脏损伤，需要血液透析。肾脏超音波显示双侧肾肥大，皮质髓质分化轻度丧失，但仍保留回声。他有持续性孤立性单核细胞增多症。肾活检显示原发肾弥漫性大B细胞淋巴瘤广泛浸润。他需要进行18天的血液透析，并接受了环磷酰胺、阿霉素、长春新碱、强的松、利妥昔单抗和鞘内氨甲喋呤的化疗。他获得了缓解，估计肾小球滤过率为50 毫升/分钟/1.73 m2，肾脏恢复正常大小。由肾脏局限性血淋巴疾病引起的肾肥大症极为罕见，尤其是在儿童中。
A 4-year-old boy presented with fatigue and was found to have severe kidney injury requiring haemodialysis. A renal ultrasound demonstrated bilateral nephromegaly with mild loss of corticomedullary differentiation but preserved echogenicity. He had a persistent isolated monocytosis. Renal biopsy revealed extensive infiltration by primary renal diffuse large B-cell lymphoma. He required haemodialysis for 18 days and received chemotherapy with cyclophosphamide, doxorubicin, vincristine, prednisone, rituximab and intrathecal methotrexate. He achieved remission with an estimated glomerular filtration rate of 50 mL/min/1.73 m2, and his kidneys returned to normal size. Nephromegaly due to renal-limited haematolymphoid disease is extremely rare, especially in children.