The neuronal control of cardiac functions in Molluscs
The neuronal control of cardiac functions in Molluscs
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DOI：
10.1016/j.cbpa.2011.06.014
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发表时间：
2011-10-01
影响因子：
2.3
通讯作者：
Kodirov, Sodikdjon A.
中科院分区：
文献类型：
--
作者：
Kodirov, Sodikdjon A.
在这篇手稿中，我回顾了当前和相关的关于软体动物心脏及其中枢神经系统特性的经典研究，包括神经节、神经元和参与心脏调节的神经。与哺乳动物的大脑半球相似，这些无脊椎动物拥有对称的神经节对，尽管内脏神经节(只有一个)和顶神经节(右神经节大于左神经节)。此外，有两个主要的调节驱动因素进入心脏的隔室(心外膜、心耳和心室)和心肌细胞。这些是兴奋性和抑制性信号，来自少数指定的神经元及其推定的神经递质。其中许多神经元被很好地识别，它们在相应神经节中的特定位置被映射，一些被称为心脏兴奋性(HE)或抑制性(HI)细胞。其余的神经元被归类为心脏调节，它们对心脏功能的直接和间接作用已经被记录在案。常用的实验动物Achat ina、Aplysia、Helix和Tymneea的心血管解剖结构相对简单。然而，与人类一样，它拥有所有主要组成部分，甚至包括小梁和房室瓣膜。由于心肌细胞是酶可分散的，描述了分离的心肌细胞中的多个电压依赖的阳离子电流。后者至少包括A型K+通道、延迟整流型K+通道、河豚毒素敏感的Na+通道和L型钙通道。由爱思唯尔公司出版。
In this manuscript, I review the current and relevant classical studies on properties of the Mollusca heart and their central nervous system including ganglia, neurons, and nerves involved in cardiomodulation. Similar to mammalian brain hemispheres, these invertebrates possess symmetrical pairs of ganglia albeit visceral (only one) ganglion and the parietal ganglia (the right ganglion is bigger than the left one). Furthermore, there are two major regulatory drives into the compartments (pericard, auricle, and ventricle) and cardiomyocytes of the heart. These are the excitatory and inhibitory signals that originate from a few designated neurons and their putative neurotransmitters. Many of these neurons are well-identified, their specific locations within the corresponding ganglion are mapped, and some are termed as either heart excitatory (HE) or inhibitory (HI) cells. The remaining neurons are classified as cardio-regulatory, and their direct and indirect actions on the heart's function have been documented. The cardiovascular anatomy of frequently used experimental animals, Achatina, Aplysia, Helix, and tymnaea is relatively simple. However, as in humans, it possesses all major components including even trabeculae and atrio-ventricular valves. Since the myocardial cells are enzymatically dispersible, multiple voltage dependent cationic currents in isolated cardiomyocytes are described. The latter include at least the A-type K+, delayed rectifier K+, TTX-sensitive Na+, and L-type Ca2+ channels. Published by Elsevier Inc.